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2014 PSWC, Melbourne (Australia)
Presentations
April 13
FIP OPENING PLENARY CEREMONY
WORKSHOP 1: BIOSIMILAR MONOCLONAL ANTIBODIES
WORKSHOP 2: CHALLENGES OF POORLY WATER SOLUBLE DRUGS
Cyclodextrins as a means of solubility enhancement
Drug delivery systems for enhancing the bioavailability of poorly water soluble drugs
Solid dispersions as a means to enhance solubility and exposure
The impact of supersaturation on oral absorption of class 2 drugs: in vitro-in vivo correlations
The principles underpinning the use of lipid based formulations
WORKSHOP 3: TRANSLATIONAL MODELLING
Introduction to modelling and translational models
Optimal design of phase i to iii studies in patient groups with limited sampling opportunities
WORKSHOP 4: TRANSPORTERS IN DRUG DISPOSITION
Drug transporter proteomics for discovery and profiling
In silico approaches to predict transporter interaction
Methods and models for assessing hepatobiliary drug transport processes
Methods for assessing bbb drug transporters and approaches to overcome the function of drug efflux transporters
April 14
AUSTRALIAN SHOWCASE: DRUG DISCOVERY AND DEVELOPMENT IN AUSTRALIA
Building a global drug discovery company from australia
Glycopeptide and lipopeptide antibiotics with potent activity against multi-drug resistant bacteria responsible for uti, csssi and cap/np infections
Pharmaceutical sciences in australia: drug discovery and development from an australian perspective
BPS / BPP PLENARY
FIP KEYNOTE: BEYOND COST ARBITRAGE: GLOBALLY NETWORKED POLYCENTRIC R&D ADDRESSING AFFORDABILITY AND ACCESSIBILITY
Beyond cost arbitrage: globally networked polycentric r&d addressing affordability and accessibility
FIP KEYNOTE: COMPARING NANOPARTICLE AND CLASSIC MICROPARTICLE IN VIVO FATES
FIP KEYNOTE: DRUG DELIVERY TO THE BRAIN: IS THE BLOOD-BRAIN BARRIER A FRIEND OR FOE?
FIP KEYNOTE: REGULATORS, PAYERS AND INDUSTRY
FIP-ED KEYNOTE
KEYNOTE: RE-INVENTING CLINICAL DRUG DEVELOPMENT:IT
MINI-SYMPOSIUM: CHALLENGES IN BIOEQUIVALENCE FOR INHALED PRODUCTS
Ivivcs and the potential impact of variability in regional airway deposition patterns on the bioequivalence of pulmonary products
The role of pharmacokinetics in bioequivalence of studies of inhalation drugs
MINI-SYMPOSIUM: PK-PD TO ENHANCE MODEL-BASED DRUG DEVELOPMENT
MODERATED DEBATE: CARRIER MEDIATED TRANSPORT THROUGH MEMBRANES: THE EXCEPTION OR THE RULE?
Both passive lipoidal diffusion and carrier-mediated uptake are important transport mechanisms in drug disposition
PHARMACEUTICAL SCIENCES 2020: AN AMERICAN PERSPECTIVE
PLENARY: MEDICATION SAFETY: CHALLENGES FOR THE 21ST CENTURY
PUBLIC LECTURE: SNAKES, SPIDERS AND OTHER VENOMOUS PREDATORS
ROUND TABLE: THE ROLE OF BIOPHARMACEUTICAL TOOLS IN QUALITY BY DESIGN
Horses for courses: picking the right biopharmaceutics tool for qbd in the indutrial setting
Qualifying vs verifying vs validating multi-level networked models
The biopharmaceutics risk assessment roadmap (bioram): building in clinical relevance for the patient benefit
SINGAPORE SHOWCASE
An overview of pharmaceutical education, research and development in singapore
Design and function of engineered peptide- and polymer-based biomaterials for antimicrobial therapeutics
SUBMITTED ORAL
Effects of the mobile phase composition on the determination of the kinetic rate constant of flurbiprofen-cyclodextrin supramolecular
Interaction with mixed micelles in the intestine attenuates the permeation enhancing potential of alkyl-maltosides
Multi-compartment systems for oral therapeutic delivery
Protein surfactant interaction and temperature dependent adsorption: g-scf formulation
Transforming toxins into therapeutics: potassium channel blockers as treatments for autoimmune diseases
SUBMITTED ORALS
A comparison of anticholinergic risk scales and associations to adverse health outcomes in older people
Altering medicines to meet patient needs: pharmacists are the key to ensuring quality.
Bio regulatory requirements of pressurized metered dose inhaler (pmdi) and optimizing in- vitro characterization of inhaler
Biological assessment of silica nanoparticles focused on neutrophil for ensuring safety of nanomaterials
Clinical implications of oxidized ldl in frequent-relapse minimal change nephrotic syndrome patients
Computational prediction of apparent solubility of lipophilic drug molecules in fasted state simulated intestinal fluid
Design, synthesis and antidepressant activities of some novel fatty acid analogues
Development of an in vivo assessment tool for quantitative and qualitative measurement of skin drug delivery: preliminary evaluation with microneedles
Efficacy of a scar therapy treatment: a randomized, double-blind, controlled trial
Fish oil in recent onset rheumatoid arthritis: a randomized, double-blind controlled trial within algorithm-based drug use
Influence of a herbal antimalarial on the pharmacokinetics of amodiaquine
Is pterostilbene a drug candidate superior to resveratrol: a comparison of their anti-inflammatory activities and pharmacokinetic profiles?
L-3-nbutylphthalide, a component from tcm induced neurogenesis after cerebral ischemia in rats
Mechanistic insights into mab aggregation and the development of novel predictive tools to stabilize therapeutic proteins
Novel nanovesicles of phosphonated calixarene to enhance the cellular uptake of loaded cargo
Potential risk factors of serious adverse drug reactions in thailand
Preparation and anti-tumor efficacy assessment of a multiple-unit drug delivery system for a chinese medicinal formula niuhuang xingxiao wan based on micro/nano technologies
Screening of ethnobotanically selected nigerian plants against plasmodium falciparum as a strategy for antiplasmodial lead identification
Small molecule blockers of n-type calcium ion channels
Strategic functionalization of nanomaterials for potential biomedical applications
Suppression of lipopolysaccharide-induced macrophage activation by aliphatic amine-heparin conjugates
Synthesis and anticancer activity of 2-substituted aminomethyl-5-methylenecyclopentanones as apoptosis inducers through down-regulating c-flip
The serotonin 5-ht3 receptor c and e subunits influence the response to antagonists
SYMPOSIUM: CHALLENGES FOR THE DEVELOPMENT OF DRUGS WITH LOW AQUEOUS SOLUBILITY AND/OR LOW PERMEABILITY
Development of oral drug product based on bcs concept; integrating drug permeability, solubility and dissolution
Solubility and formulate-ability: key molecular determinants of developability of ligands to contemporary targets
Solubilization for oral drug delivery: new challenges in prediction
SYMPOSIUM: DOUWE BREIMER FOUNDATION SYMPOSIUM
Integrating network and pharmacodynamic models of drug action
Pharmacoproteomics: quantitative targeted absolute proteomics (qtap) and its application to the re-construction of in vivo protein function
Systems pharmacology - towards multi-target therapeutic intervenstions
SYMPOSIUM: EMERGING MARKETS/EAST MEETS WEST
Development of the pharmaceutical product food chain
Pharmaceuticals emerging market-west meets taiwan, the gate of far east
Using of virtual chinese population for ethnic sensitivity assessment in drug development: introduction of roche
SYMPOSIUM: GENE-BASED THERAPEUTICS: POSSIBILITIES AND CHALLENGES
Co-delivery of drugs and sirna to treat multidrug resistant tumor
SYMPOSIUM: PHARMACOEPIDEMIOLOGY: BRIDGING PHARMACEUTICAL SCIENCE AND PRACTICE
Multimorbidity, polypharmacy and regimen complexity: the example of people with cognitive and functional decline
To genotype or not to genotype: pharmacogenetics of coumarins. results from observational studies and clinical trials
SYMPOSIUM: PK-PD FOR SUPPORTING CLINICAL DECISIONS AND POINT-OF-CARE DOSAGE
Design, governance and implementation of web-based decision analytics to guide pediatric pharmacotherapy
Pk-pd analysis of mechanism of toxicity of molecular target drugs: towards optimal treatment of cancer
Population pharmacokinetics and pharmacogenetics of vitamin d in hiv-positive patients
April 15
ACCELERATING DEVELOPMENT FOR CHINA AND BEYOND:PATIENT, SCIENCE, AND PUBLIC HEALTH
APSA EARLY CAREER RESEARCHER SYMPOSIUM
Dialysis-related carnitine deficiency: pharmacokinetic, pharmacological and clinical aspects
Novel inhaled combination powders for respiratory infections
APSA KEYNOTE
APSA SYMPOSIUM: BARRIER MECHANISMS TEAM UP: INTERPLAY BETWEEN TRANSPORTERS, ENZYMES AND TIGHT JUNCTIONS
Interplay of drug metabolizing enzymes and transporters
Regulatory mechanisms influencing drug transport across the blood-brain barrier
APSA SYMPOSIUM: INTRACELLULAR DRUG TRAFFICKING AND TARGETING
Controlled intracellular trafficking with multifunctional envelope-type nano devices
Intracellular lipid binding proteins as mediators of nuclear targeting
The sequestration of drugs in lysosomes: mechanisms and therapeutic consequences
BIOSIMILARS - CURRENT TOPICS AND CONTROVERSIES
Interchangeability of biosimilars - yes or no?
Update and scientific strategies for accessing the us market for biosimilars
FIP KEYNOTE: THE FUTURE OF VACCINES
INDIAN SHOWCASE
Dry powder inhalations in the treatment of pulmonary tuberculosis
Systems biology approach to solving drug discovery challenges
KEYNOTE: THERAPEUTIC MONOCLONAL ANTIBODIES: WHERE HAVE WE COME, AND WHERE ARE WE GOING?
MINI SYMPOSIUM: NOVEL NANOMATERIALS WITH DRUG DELIVERY APPLICATIONS
Albumin-based nanomaterials for targeted drug delivery
Theranostic nanoparticles designed to release therapeutic molecules and act as mri contrast agents
MINI SYMPOSIUM: PERSONALIZED MEDICINE IN THE CLINIC: READY FOR PRIMETIME?
Clinical front line and challenge of personalized medicine
The unanticipated complexities of personalised medicine in the clinic
MINI-SYMPOSIUM: BIOSIMILARS: CHALLENGES AND OPPORTUNITIES
International pharmaceutical biosimilarity
Update and scientific strategies for accessing the us market for biosimilars
MINI-SYMPOSIUM: EVOLUTION OF THE BIOSIMILAR REGULATORY LANDSCAPE
Biologicals and biosimilars, what
Regulation of biosimilars: considerations in the development of biosimilars in an evolving landscape
PHARMACEUTICAL SCIENCES 2020: A EUROPEAN PERSPECTIVE
ROUND TABLE - INTERCHANGEABILITY OF BIOSIMILARS - YES OR NO?
SUBMITTED APSA ORALS
Idiosyncratic drug induced liver injury: from population to molecular target
Stealth nanoemulsions evade intestinal lipolysis and improve drug absorption after oral administration
The involvement of fatty acid-binding protein 5 in the blood-brain barrier transport of docosahexaenoic acid
The role of caveolae in cationic peptide-based asymmetric dendrimer mediated cellular delivery
SUBMITTED ORALS
Biomimetic glyceride prodrugs facilitate targeted delivery to the lymphatics, lymph nodes and adipose tissue
Buccal mucosal delivery of a peptide for the treatment of autoimmune diseases
Cleaning tumor margins via abrogation of heat shock protein 90 with protein engineered tri-block biopolymer-geldanamycin conjugates
Cucurbituril-based dosage forms: a new macrocycle delivery vehicle to rival cyclodextrin
Design, synthesis and in vitro characterization of peptide based gene delivery systems
Designing a non-viral gene delivery system using adenoviral proteins
Development of pectin-based nanoparticles containing melatonin for the treatment of inflammatory bowel disease i. preparation and characterization studies
Development of self-adjuvanting polymer-peptide conjugates as therapeutic vaccine against cervical cancer
Discovery of potential biomarkers associated with type 2 diabetes using artificial intelligence technologies
Drug delivery to the brain by colloidal carrier systems
Effects of lipid digestion on the phase behaviour of intestinal mixed micelles: correlation of in vitro studies with and in silico molecular dynamics simulation
Electrostatically stabilized iron oxide nanoparticles for thermoresponsive cancer treatment
Enhanced lymphatic exposure of a chemotherapeutic drug with pegylated, nano-sized drug vectors
Exploration of methacrylate-based polyplexes as safe non-viral gene delivery systems
Impact of cyp3a5 polymorphisms on the treatment of chinese renal transplant recipients switching from cyclosporine to tacrolimus
Investigation of polycaprolactone matrices containing doxycycline and metronidazole for the treatment of pelvic inflammatory disease
Liposomal delivery of anti-cancer drug combinations: formulation considerations & mechanisms of action
Novel injectable pentablock copolymer- based thermoresponsive hydrogels for sustained vaccine delivery
Sirtuin 2 inhibitory activity of functionalized tetrahydro-y-carbolines.
Strategies for translational biomarker research and validation for personalised medicines
Sugar-based amphiphiles for drug delivery: synthesis, characterisation and prospects
The analysis on nasal drug absorption using positron emission tomography: the pharmacokinetic investigation and the possibility of direct drug transport to the brain
The development of electrospun zein nanofibres for pharmaceutical applications
Therapeutic antibody drugs based on targeted molecular epitopes
Topical nanomedicine - overcoming the barriers
Understanding the de-agglomeration kinetics of dry coated powders
SUNRISE SESSION: MEET THE EXPERT
Sunrise Session: Meet the Expert
SYMPOSIUM: ACADEMIA AND PHARMA COLLABORATIVE MODELS - FINDING THE RIGHT BALANCE
Cooperative research centres - the australian model applied to drug discovery
Cross-sector collaborations in pharma designed to maximize benefits for patient
SYMPOSIUM: DRUG DEVELOPMENT EFFORTS TO COMBAT TROPICAL DISEASES
Drug development efforts to combat malaria
Drugs for neglected tropical diseases: new approaches, current status and challenges
SYMPOSIUM: ENABLING PERSONALIZED MEDICINE: GETTING THE FRAMEWORK RIGHT?
Developing evidence to inform the clinical utility and cost-effectiveness of pharmacogenomic markers: challenges and opportunities
How therapeutic drug monitoring can help to personalise dosing of anti-tnf monoclonal antibodies in patients with chronic inflammatory diseases
Improving drug safety through personalized medicine approaches
SYMPOSIUM: IMMUNOGENICITY MITIGATION STRATEGIES FOR BIOSIMILARS
Immunogenicity of biosimilars: considerations related to evaluation strategy and challenges
Multidisciplinary approach to evaluating immunogenicity of biosimilars: lessons learnt and open questions based on 10 years experience of eu regulatory pathway
SYMPOSIUM: NANOTECHNOLOGIES FOR DRUG DELIVERY
Development of pegylated adenovirus vector containing targeting ligand on the tip of peg chain
Remodeling tumor microenvironment to improve therapy
Skin is special: exploiting it with practical microneedle devices for improved vaccines, and diagnosis of disease
SYMPOSIUM: SAFETY OF NANOMEDICINES: REALITY CHECK?
Challenges in preclinical characterization of nanomedicines
Nanoparticles and skin: unmoveable objects and irresistible barrier
The value of not over-engineering - simple biocompatible nanoconstructs overcome mgst-1 mediated resistance in breast cancer
April 16
DDA KEYNOTE: BLOCK COPOLYMER MICELLES AS SMART NANO CARRIERS FORTARGETED DRUG DELIVERY
DDA SUBMITTED ORALS
An aptamer-based sirna in vivo delivery system targeting cancer stem cells
Aqueous remote loading of protein therapeutics in plga microspheres
Enhanced local delivery of topical anaesthetics
Fabrication of mupirocin-encapsulated plga nanoparticles for the delivery to biofilms
Liposome based vaccine delivery system against malaria
Polymer-functionalised silica lipid hybrid materials that enhance the solubilization and oral absorption of poorly water soluble drugs
Surface acoustic wave (saw) atomization of therapeutic antibodies for pulmonary delivery
DDA SYMPOSIUM: PULMONARY DRUG DELIVERY
Drug absortion in the lungs - uptake and efflux transporters
Ex-vivo and in vivo sirna delivery to activated t cells as novel anti-inflammatory asthma therapy
Inhalation of rifapentine dry powder to shorten tuberculosis treatment
DDA SYMPOSIUM: SELF-ASSEMBLED DRUG DELIVERY SYSTEMS
Controlling structural transformations between bicontinuous and other lipid liquid crystalline materials for drug delivery
FIP KEYNOTE: A GENOMICS VIEW OF DRUG THERAPY
FIP KEYNOTE: A GLANCE ON CURRENT PROGRESS OF INNOVATIVE DRUG R&D IN CHINA
FIP KEYNOTE: PHYSICAL PHARMACY AND PHARMACEUTICS, GRAND ACHIEVEMENTS, AND NOW FOR THE FUTURE
FIP KEYNOTE: UNDERSTANDING THE PHYSICOCHEMICAL AND BIOLOGICALDETERMINANTS OF PHARMACOKINETICS: FROM HUMANS TO ORGANS, CELLS AND NANOSYSTEMS
Understanding the physicochemical and biological determinants of pharmacokinetics: from humans to organs, cells and nanosystems
MINI SYMPOSIUM: DRUG DISCOVERY IN ACADEMIA
Drug discovery in academia: growing pains
Roles of polyamines in drug design and discovery toward neurological disorders
MINI SYMPOSIUM: MOLECULAR AND FUNCTIONAL IMAGING IN DRUG DEVELOPMENT AND EARLY CLINIC
PHARMACEUTICAL SCIENCES 2020
ROUND TABLE / DEBATE
Novel low-cost approach for in-vitro determination of bioavailability for immediate release solid oral dosage forms
ROUND TABLE / DEBATE: DOES ALTERED PHYSIOLOGY ALWAYS EQUATE TO ALTERED DRUG DISPOSITION?
Alteration of hepatic drug clearance in liver disease: intact hepatocyte hypothesis or sick cell hypothesis?
ROUND TABLE: IUPHAR / FIP: TRANSLATION THROUGH COOPERATION
Translation through cooperation - how can clinical pharmacology and pharmaceutical sciences work together more effectively?
SHOWCASE CHINA
Computational methods for drug design and discovery: a focus on china
Crystal structures of hiv-1 co-receptors ccr5 and cxcr4: implications for anti-hiv drug discovery
Progress of regulatory science research in the field of biological products in china
The virtue of translational toxicology in drug discovery: selecting the right cinical candidate while reducing risk
SUBMITTED ORALS
Amitriptyline and ketamine hydrogel: new formulation for peripheral neuropathic pain
Development of a novel self-dissolving microneedle array of alendronate, a nitrogen-containing bisphosphonate
Preparation of novel polymeric microparticles for slow-release intrathecal delivery of analgesics
SUBMITTED ORALS
Anticoagulant activity of coumarin from kluwak (pangium edule reinw.) seeds based on prothrombin time in rat
Berberine is a new medicine for energy-related metabolic disorders
Development of a new pharmacokinetic model incorporating nasal physiologic function to predict nasal drug absorption
Enhanced uptake and transport of (+)-catechin and (-)-epigallocatechin gallate in niosomal formulation by human intestinal caco-2 cells
Fgf21 maintains glucose homeostasis by mediating the crosstalk between liver and brain during prolonged fasting
From inflammation to depression - hypericum perforatum l. extract as a therapeutic ap-proach
Glucosidation and glucuronidation represent parallel metabolic pathways for the metabolism of mycophenolic acid and morphine by human udp-glucuronosyltransferases
Human biliary excretion of unchanged drug can be predicted prior to human dosing
Immunomodulators and/or probiotics as adjunctive therapy for eradication of h.pylori and improvement of immune system in peptic ulcer disease
Impact of inflammation and concomitant glucocorticoid on pharmacokinetic disposition of voriconazole and itraconazole in immunocompromised patients
Inhibition of bacterial cytokinesis by curcumin analogues
Investigating the structural and thermodynamic basis of substrate selectivities of human cytochrome p450 enzymes: a molecular dynamics study
Population pharmacokinetics of imatinib mesylate in nigerian patients with chronic myeloid leukemia
Safety and efficacy results of a phase iv safety-monitoring study of icotinib in treating advanced non-small cell lung cancer
Simultaneous and comprehensive in vivo analysis of cytochrome p450 activity by using a cocktail approach in rats
SUNRISE SESSION: MEET THE EXPERT
SYMPOSIUM: CROSSING THE BRIDGE
Harmonization of asia bridging study 2013 fip/aaps/tfda sponsored workshop report and future prospectives
Inter-ethnic differences in drug response, bridging studies and drug development in east asia
Regulatory perspective on use of foreign clinical data for drug approval: pmda
SYMPOSIUM: HERB-DRUG INTERACTIONS: ARE THEY DANGEROUS?
Herb-drug interactions, beneficial for detrimental?
Herb-drug interactions: complexities of in vitro-in vivo extrapolation
SYMPOSIUM: NATURAL PRODUCTS - SUSTAINABLE USE OF MEDICINAL PLANT RESOURCES
Easy to grow but endangered: field survey and relevant experiments on Agarwood
Locally-driven research on medicinal plants from Kuuku I'Yu (Northern Kaanju) homelands, Cape York Peninsula, Australia
Managing sustainable use of finite resources - responsibilities for importing countries and a Japanese case
SYMPOSIUM: NEW MOLECULAR AND CELLULAR TARGETS FOR THE TREATMENT OF HUMAN DISEASE
Allosteric drug discovery at g protein-coupled receptors
Amyloid-ß and tau - a toxic pas de deux in Alzheimer's disease
Targeting the cell cycle machinery for the treatment of cardiovascular disease
SYMPOSIUM: NON-ADHERENCE - THE LARGEST CONTRIBUTION TO VARIABILITY IN DRUG RESPONSE
Scope of patient non-adherence to prescribed drug dosing regimens
The CMC issues surrounding adherence associated with pediatric and geriatric populations
Utilising technology to improve adherence and patient outcomes
SYMPOSIUM: TRANSPORTERS AS MEDIATORS OF CLINICAL DRUG-DRUG INTERACTIONS
Cellular models and clinical relevance of renal transporter-mediated drug-drug interactions
Drug interactions in hepatobiliary transport: mechanisms and clinical relevance
Posters
Analytical Sciences and Pharmaceutical Quality
A validated lc-ms/ms method for the quantitation of a-galactosylceramide incorporation in liposomes
Biodistribution studies of isotopes labeled newly synthesized polymer-coated spion in sprague-dawley rats
Classification of risks in global integral supply chain of medicinal products
Clinical and humanistic outcomes of pharmaceutical care in type 2 diabetes mellitus patients: a randomized controlled pilot study at federal teaching hospital abakaliki, ebonyi state nigeria
Comparison of the efficacy of controlled drug denaturing kits
Control release of compounds in living cell using photodegradable silica nanoparticles
Determination of melamine in milk samples and the risk assessment
Development and validation of an lc-ms/ms bioanalytical method for quantification of homocysteine (hcy) in samples of human serum
Development of methods for the quality control of film curing using spin coating and atomic force microscopy
Effect of short-term temperature excursions on the long-term stability of vaccines
Nitazoxanide stabilizing hypsochromic shift based method for its determination in bulk and in pharmaceutical formulation
Structural change of biopharmaceuticals using ion mobility mass spectrometry analysis
Biotechnology (Vaccine)
Antibody drug development in china
Construction of fluorescent uricase fusion protein for characterization of urate transporters
Construction of human interferon alpha 2b-encoded gene for expression in periplasmic compartment of escherichia coli bl21, characterization and overproduction
Designing a novel freeze-stable tetanus vaccine
Evaluation of in vitro cytotoxicity of nasal ovalbumin formulations on calu-3 cells
Gene therapy: pegylation of cationic dna lipoplexes can increase the distribution and transfection efficiency in the muscle
Maintenance of stemness by rho kinase inhibitor thiazovivin in bovine embryonic pluripotent stem cells
Nanostructured lipid in double emulsion: multi-compartment system for oral vaccine delivery
Preparation of self-assembled chitosan nanoparticles as a vaccine candidate against group a streptococcus
Production of extracellular serratiopepridase by novel strain of mangrove soil isolate
Quantitative evaluation of in vivo fate of mouse melanoma b16-bl6-derived exosomes after intravenous injection into mice
Secure and effective gene vector of polyamidoamine dendrimer pharmaceutically modified with anionic polymer
Drug Design and Discovery
A comparative study between the local muscle paralytic activity of crude paralytic shellfish poison extract and botulinum toxin type a
A novel class of anti-tb drug candidate targeting dpre1 enzyme
A novel interferon-alpha inhibitor reduces histopathological complications in a mouse model of hiv encephalitis
A novel microtubule polymerization inhibitor with potent antiproliferative and antitumor activity, but not a substrate for pgp and mrp
A novel non-immune phage human antibody library comprising four stable vh-vl pairs
A novel synthetic prodrug of flurbiprofen with good oral drug-like behaviors and improved safety profile
Characterisation of the guanylate cyclase catalytic activity in irak3
Computation of pharmacophore models for the prediction of pde4 inhibitory activity of indolizine derivatives
Cytotoxic activity of novel 1,3-thiazolyl compounds
Design and synthesis of 2-aroyl-3-arylquinoline derivatives as anti-dengue virus agents
Design, molecular docking and synthesis of some new diazepine derivatives with their potential biological activity
Design, synthesis and antitumor activity research of psammaplin a derivatives
Fluid flow in a spiral device used for irradiation of biological fluids
Identification and characterisation of cytochrome-p450 metabolites of the ozonide antimalarial drug candidate oz439 (using chemical derivatisation and lc/ms)
Identification of 5,6-quinolinedione as a potential reactive metabolite of primaquine
Identification of annexin a4 as cisplatin-susceptibility related protein in malignant mesothelioma
Imidazole napthyridine derivatives regulate calcium ion flux and cell death in cultured cardiomyocytes
Investigation of 17?-estradiol and cholesterol complex by hot stage polarized light microscope
Investigation of potential therapeutic targets for glioblastoma using a mouse ipsc-derived model of glioblastoma initiating cells
Lipophilic prodrugs for oral chemotherapy: synthesis, stability and cytotoxicity
Making anticancer drug 5-fluorouracil (5-fu) selective for cancer cells only in human body
Molecular modeling and structural requirement of gsk-3
Novel baicalein analogs as potential anti-viral agents
Novel in vitro model for estrogen (e) stimulated cancers applied to screening dicathis orbita derived bioactive molecules and synthetic analogues for anti-cancer activity
Orally formulated bifidobacteria and lactobacilli decrease the bioavailability of the bile acid, mkc, in healthy and diabetic rats
Quantitative structure-activity relationship study on environmental fate of chemical substances
Relationships between molecular descriptors, drug-likeness scores, admet parameters and biological activity of tyrosine kinase inhibitors in a series of quinoline, quinazoline, pyrido- and pyrimido-pyrimidine derivatives
Retinoic acid activity on mamalian embryo in organ culture and evaluation of hazard and risk in correlation studies between molecular descriptors and admet parameters in a series of x-category drugs
Subunit vaccine design of the schistosomiasis japonica insulin receptor
Synthesis and characterisation of sterically hindered pyridine based multinuclear platinum anticancer complexes and their cytotoxicity
Synthesis of some thiazole derivatives with their computational and biological studies
Synthesis, computational studies and pharmacological evaluation of some acetamides as serotonin antagonists
Synthetic studies on natural pyranonaphthoquinones via diels-alder approach
Targeted delivery of mycophenolic acid to the lymphatic system using lipid mimetic prodrugs: triglyceride vs phospholipid analogues
Therapeutic impact of human serum albumin-thioredoxin fusion protein, long-acting anti-oxidative and anti-inflammatory modulator, against acetaminophen-induced acute hepatopathy
Thermal screening of estradiol-saccharin cocrystal by differential scanning calorimetry
Transport of glycosylated luteinizing hormone releasing hormone analogues in caco-2 cell model
Treatment of arthritis with non-anticoagulant heparin lipid nanoparticles through suppression of the tlr4
Unravelling the gc functionality in the neurotrophic tyrosine kinase, ntrk1
Utility of plasma as transport medium in the caco-2 monolayer test system
Formulation Design and Pharmaceutical Technology
A comparative evaluation of the effect of massing time on granulation of soluble and insoluble powder system
A functionalized stimuli responsive polymeric nanocarrier with anti-angiogenic activity for therapy and pet imaging
A multi-functional micro-excipient for tablet manufacturing: applying the concept of interactive mixing
A nanosystem for hydrophobic drugs using a solid lipid and supercritical fluid
A rapid screening method utilizing dual macromolecular markers for development of therapeutic methods of peritoneal injury
A thermodynamic and kinetic analysis of human epidermal penetration - penetrant structure relationships
Absorption and transepithelial transport of poorly soluble drugs: the dispersion of the solid particle and dissolved drugs
Addition of an absorption sink to the in vitro digestion model leads to an improved understanding of drug absorption from oral lipid-based delivery systems
Amorpohous solid dispersion of dtx: an approach to improve bioavailability
Application of fenofibrate solid dispersion for bioavailability enhancement by hot-melt extrusion
Application of ivivr in the development of generic transdermal drug delivery system: a case study of rivastigmine
Application of pressurised gyration as a novel means of producing pharmaceutical polymeric nanofibres
Biodistribution and biostability evaluations of sirna based on near-infrared florescence imaging analysis
Bridging nano to millimeter: three dimensional structural architecture research opens new visions for drug delivery
Cancer therapy: not only cancer cells but cancer stem cells
Cds in the management of parkinson
Characterisation of onychomycotic nailplates
Characterisation of palm-olein-in-water emulsion as a vehicle for topical drug delivery of betamethasone 17-valerate
Characterization of hydrogle-embedded liposomes: influence of formulation properties on peritoneal retention
Characterization, solubility and dissolution behavior of ketoprofen cocrystals
Chitosan-based polyelectrolyte complexes as potential nanoparticulate carriers: physicochemical and biological characterization
Chitosan-fap-b nanoparticles: novel non viral vectors for gene delivery to the lung epithelial cells
Comparative study of in-silico and in-vitro anticancer activity of traditional indian medicinal plants - a reverse pharmacological approach
Controlled protein delivery from novel photocured biodegradable poly (decane-co-tricarballylate) elastomers
Design and evaluation of mucoadhesive microspheres of amphotericin b
Design oral antigen nanoparticles for inducing systemic immune response
Determination of the sealing effect of chicken skin gelatin with poly(l-glutamic acid) glue mixture for umbilical hernia repair on sprague-dawley rats
Development and characterization of curcumin-loaded nanogel for treatment of inflammatory and neoplastic diseases
Development and evaluation of injectable hydrogels for repair and replacement of damaged intervertebral disc
Development of 5-fluorouracil topical nanoemulsion for the treatment of nonmelanoma skin cancer
Development of a floating drug delivery system based on gas formation or sublimation technique
Development of a novel integrated platform for the simultaneous delivery of water-soluble carboplatin and water-insoluble paclitaxel
Development of controlled release nimodipine microparticles by microencapsulation technique: optimization, release kinetics and characterization
Development of felodipine nanoparticles using biodegradable carrier: in vitro and in vivo assessment
Development of floating drug delivery system of metformin hydrochloride using herbal carriers
Development of metronidazole-loaded alginate wound dressing: formulation characterization and in vivo healing evaluation.
Development of novel stabilisers for lyotropic liquid crystalline dispersions.
Development of osmotic controlled drug delivery by quality by design approach for an antihypertensive agent
Development of spray freeze dried powders for inhalation with hygroscopic drug
Development of transungual drug delivery system of terbinafine for onychomycosis
Development of trastuzumab conjugated dendrimer nanoconjugates for targeted delivery of docetaxel
Development of valacyclovir nanoemulsion for effective ocular delivery
Dimensionless binding values in the evaluation of paracetamol tablet formulation
Drug precipitation and solid state transformations during digestion
Effect of alcohol on skin permeation and metabolism of p-hydroxyl benzoic acid methyl ester
Effect of bilayer disruptors on the sensitivity of liposomes to ultrasound
Effect of sample treatments on the dissolution behaviors of selfpnanoemulsifying drug formulation
Electronic tongue assessment of liquid formulations of amlodipine salts
Elucidating the mechanism of the effect of device design on dry powder inhaler performance using a coupled cfd-dem computational modelling
Encapsulation of hydrophilic drug into plga-peg-fol nanoparticles by nanoprecipitation
Endocytosis of paclitaxel loaded into solid lipid nanoparticles (slns) in multidrug resistant human breast cancer cell line, mcf-7/adr
Engineering of a novel, sterically hindered disulphide bridged amino acid: enhanced biostability leading to new generation bioreducible peptides and drug/gene carrier systems
Enhancement of percutaneous penetration of actarit from hydrophilic gel using penetration enhancers
Enhancement of tumor suppressive effect of tocotrienols via tumor-targeted nanocarrier-based delivery system
Enhancing the dissolution of anti cancer flavonoid naringenin utilizing self nanoemulsifying drug delivery system (snedds) and solid dispersions- a comparative evaluation
Evaluation of alternative type iii lipid formulations which can be designated as superior carrier to improve solubility and availability of anti cholesterol drug fenofibrate for absorption
Evaluation of selected properties of calcium alginate gel films made by two different techniques
Formulation and evaluation of metoprolol succinate sustained release tablet and hydrochlorothiazide immediate release bilayer tablet
Formulation and evaluation of microballoons of ramipril
Formulation and optimization of raloxifene loaded nanotransfersomes by response surface methodology for transdermal drug delivery
Formulation and pharmacokinetic evaluation of solid lipid nanoparticles containing an antipsychotic agent for improved oral delivery
Formulation of nano-sized bubble liposomes as an echogenic platform delivery system: stability, drug loading and in vitro evaluation
Formulation strategies for aeroperl
Formulation, optimization and characterization of lipid nanoparticles of clioquinol for alzheimer's disease
Functionalized of poly(glycerol adipate) microparticle for delivering drug to cell aggregate
Hemocompatibility of n-trimethyl chitosan chloride nanoparticles
Hollow nanostructured materials functionalized pmma-based bone cements for effective drug delivery
Improved cellular uptake of curcumin into colorectal cancer cells when formulated in mucoadhesive chitosan nanoparticles
Improved dissolution and oral exposure of telmisartan, a poorly soluble drug through the formation of drug-clay complex
Improved oral bioavailability and reduced nephrotoxicity of self-emulsifying formulation of cyclosporin a in combination with antioxidant following oral administration
In silco modelling to predict the drug plasma concentrations of dextromethophan in populations with pharmacogenomic variations.
In vitro transport studies across excised nasal mucosa for three drug candidates to nose-to-brain delivery
Influence of coating materials on the flowability and dissolution of dry coated fine ibuprofen powders
Influence of the surfactant tween 80 on aqueous self-assembly of phytantriol
Inhibition of cyclooxygenase-1 enzyme by flurbiprofen loaded ophthalmic nanoparticles
Innovative strategy for improving the oral delivery of amphotericin b: design, development and evaluation of functional hydrophobic prodrugs
Insulin nanoemulsion to improve insulin
Intranasal microemulsion based brain delivery system of rivastigmine: formulation and ex-vivo characterization
Investigating the effects of cholesterol on non-lamellar liquid crystalline nanoparticles as potential drug delivery systems
Involvement of water molecular mobility in the properties of photocrosslinked polyacrylic acid hydrogel for use in dermatological patch adhesive
Itraconazole-hydroxypropyle-beta-cyclodextrin loaded deformable liposomes: in vitro skin penetration studies and antifungal efficacy
L-asparaginase-fatty acid bioconjugates in nanostructured mixed micelles: synthesis, biochemical/biophysical characterization, immunogenicity and pharmacokinetic analysis of peptidic anticancer agent
Lipidation of a peptide; effects on activity and epidermal permeability in vitro
Lipoprotein association plays a critical role in promoting lymphatic transport of a biomimetic prodrug of mycophenolic acid
Magnoliae cortex extracts induce drug-metabolizing enzyme activity in pc12 cells
Measurement of the solid solubilities of cinnarizine in supercritical carbon dioxide
Medicago spp extracts as a source of isoflavones
Metformin in semi-solid matrices: a new approach for improved bioavailability and extension of its anti-diabetic action
Microemulsion using sucrose laurate and its application on skin delivery of resveratrol and chlorogenic acid
Modulating tetracaine aggregation using nanoparticles to enhance topical administration
Nanomedicine: a technology for tomorrow
Nanoparticles electrostatically coated with folic acid for effective and safe gene delivery
New in vitro tridimensional co-culture intestine cell model for studying the permeability of drugs and nanoparticles
Novel inhaled combination powders containing colistin with enhanced antimicrobial activities on both planktonic cell and biofilm of pseudomonas aeruginosa
Optimization of spray dried microspheres for pulmonary inhalation development: exploring a new drug delivery route for melatonin
Orally fast dissolving film containing drug nanoparticles:preparation and in vitro/in vivo evaluation
Paracetamol dosage form modifications for patients unable to swallow: from crushed tablets to thickened liquid medications
Photostability of furosemide cocrystals
Physicochemical analysis of indomethacin-loaded lipid nanoparticles engineered by a novel microwave technology
Polyelectrolyte complex micelles by self-assembly of polypeptide-based triblock copolymer for doxorubicin delivery
Possible mechanisms of high drug permeability obtained from dry powder formulations for inhalation in air-interfaced cell culture system
Potential applications of nanoshells in biomedical sciences
Predicting the phase behavior of colloidal systems using hybrid neural networks
Prediction of drug loading in single excipients and lipid based formulations
Preparation and characterization and evaluation of cefixime in chitosan nanoparticles
Preparation and characterization of gold nanoparticles conjugated with vincristine stabilized by gum acacia as targeted anti cancer drug delivery system
Preparation and characterization of multivesicular vesicles (mvvs) containing gentamicin as a depot drug delivery system
Preparation and evaluation of salicylic acid niosomes as a topical delivery system.
Preparation of olanzapine-loaded sucrose fibres using a cotton-candy floss machine
Pulsatile drug delivery system of ibuprofen and famotidine
Qbd: production of monosized spherical granules and control of dissolution rate via steady state wet granulation
Quality by design approach for formulation development of extended release dosage form for an antimuscarinic agent
Quality by design based optimization and correponding performanceof camptothecin loaded solid lipid nanoparticles
Quality control of processed chinese materia medica using zingiberis rhizoma as a case study
Rapid expansion of supercritical solutions (ress) as a tool for simultaneous cocrystallization and micronization of poorly soluble drugs: (i) cocrystal production and identification
Rapid expansion of supercritical solutions (ress) as a tool for simultaneous cocrystallization and micronization of poorly soluble drugs: (ii) dissolution performance and solubility enhancement
Recrystallization of primidone using the supercritical antisolvent (sas) process
Salted polyethylene oxide for modulation of levodopa release from interpolymeric blend matrices
Selection of polymeric precipitation inhibitors for use with poorly water soluble drugs
Simulation of oral felodipine plasma concentrations in the yucatan mini-pig
Simvastatin-loaded chitosan nanocapsules for an innovative administration of statins
Solid self emulsifying drug delivery systems of fenofibrate as strategy to improve dissolution rate and bioavailability compared to the marketed product lipanthyl using adsorbent carrier, neusilin
Spray-dried carrier-free dry powder formulation: a quality by design (qbd) approach to investigate the effects of process variables on product characteristics.
Stability of oxytocin: aqueous vs. solid state
Structural investigation into the influence of lipolysis products on the structure of bile salt micelles
Study of the transdermal transport and permeation of a-mangostin and gartanin from garcinia mangostana l
Sulforaphane modulation of oligomeric amyloid-
Surface treated methotrexate-loaded nanogels as 'trojan horses' for brain drug delivery
Synthesis and characterization of xanthan gum stabilized gold nanoparticles for the delivery of anticancer drugs
Synthesis of novel polymeric precipitation inhibitors for improved kinetic stabilisation of supersaturated poorly water soluble drug solutions
Targeted biodegradable plga-poloxamer nanoparticles
The alkaloid composition of nicotiana gossei and duboisia hopwoodii used in the production of pituri by australian aboriginal people
The effect of particle size on the physical and drug-release behaviour of chloramphenicol-loaded mini-tablets for ocular use
The formulation of bacteriophage into semi-solid preparations for the control of bacterial infections
The impact of different polymers and drug physical state on the dissolution enhancement of solid dispersions
The lfcs consortium: in vitro dispersion tests are an effective first screen during lipid-based formulation development and evaluation
The lfcs consortium: rank order correlation of in vitro and in vivo performance identified using in vitro digestion testing
The relationship between size of oil droplet and the pharmacokinetic profile of curcumin nanoemulsion after intravenous and oral administrations to male healthy wistar rat
Tools for successful colonic delivery in the treatment of ibd
Topical delivery of curcumin with palmitoyl glycol chitosan for the treatment of skin cancer
Transdermal delivery of herpetrione for liver targeting: ultrasound conductivity meter combined with nanotechnology
Transition temperature microscopy: a novel tool for monitoring drug crystallisation in the stratum corneum
Triggered release from nanostructured capsules formed at interfaces between oppositely charged surfactant and polymer solutions
Ultrasound triggered doxorubicin loaded microbubbles: a novel strategy toward more effective therapeutic outcomes in cancer
Ultrassonication-assisted polylectrolytes nanoparticles:influence of coating on ibuprofen release.
Understanding the efficacy of oral delivery systems for targeting colorectal cancer cells by using a dual fluorescence labeled nanoparticle-microcapsule system
Unique effects of arabinogalactan on pharmacological properties of drugs
Use of powder bed tensile strength to explain the improved de-agglomeration of intensive dry coated salbutamol sulphate using magnesium stearate
Natural Products
A chemometrics approach to the analysis of cannabis sativa samples. metals and organic compounds in the biosynthesis of cannabinoids
Alpha mangostin improves glucose uptake and inhibits adipocytes differentiation in 3t3-l1 cells
Anti-asthmatic activity of sarcostemma brevistigma in egg albumin induced asthma in guinea pigs.
Anti-inflammatory activities of some ethnomedicinally used plants found in kaski district of nepal
Assessment of pharmacodynamic and pharmacokinetic interaction of metformin and aqueous extract of trigonella foenum graecum in rats.
Chemical diversity and the bioactive compounds from marine invertebrates inhabited in south china sea
Coumarin formation during boiling and ripening processes of kluwak (pangium edule reinw.) seeds
Cytotoxic properties of the leaf essential oils of two amazon guatteria species
Dihydrotanshinonei enhances the radiation sensitivity of human cervical cancer by apoptosis induction
Diversity of conotoxin gene superfamilies in conus victoriae
Effects of tetrahydroeurcumin on kk-ay mice
Enhancement of dissolution rate and oral bioavailability of lovastatin in red yeast rice products
Enhancing the anticancer and antiangiogenic efficacy of phytoalexin resveratrol for cancer chemoprevention using nanoemulsification
Enzymes inhibition and antidiabetic effect of isolated constituents from hibiscus tiliaceus
Evaluation of the antitumour efficacy of the crude extract, fraction and piplartine obtained from piper tuberculatum by in vivo hollow fiber assay
Hepatoprotective activity of citrullus colocynthis roots on acetaminophen induced acute hepatic injury in experimental rats: a biochemical and histopathological approach
Herbal medicinal products and botanicals: why are clear boundaries necessary?
Immunosuppressive effect of five ergosterols isolated from lentinus polychrous mycelial extract and theirs in vitro cytotoxicity
In vitro and in vivo anti-inflammatory evaluation of cladogynos orientalis extract
In vivo wound healing activity and phytochemical screening of the crude extract and various fractions of kalanchoe petitiana a. rich (crassulaceae) leaves in mice
Incorporation of rosmarinic acid in sln witepsol nanoparticles
Inhibitory effects of piperine on ige-mediated degranulation of rbl-2h3 cell
Investigation of traditional australian aboriginal and indian ayurvedic medicinal plants for their role in management of type ii diabetes
Isolation and characterization of 1-(6-hydroxyphenyl)-3-(4-hydroxyphenyl)-2- propen-1-one from tecoma stans: screening for phenolic compounds using conventional and advanced instrumentation
Lecithin controls overexpression of bax in chang liver cells to demonstrate hepatoprotective ability
Leonurine, a novel therapeutic strategy on stroke: from bench to bedside
Novel anti-inflammatory functions for the herbal drug stw 5: a link between cytokine regulation and gastrointestinal inflammation
One case of the patient compliance instruction succeeded in using sign languages to a hearing-impaired patient in kagawa university hospital
Pharmacoeconomic and efficacy evaluation of anti-obesity treatments in obese population in india
Potential elicitors to enhance production of plumbagin in plumbago indica root cultures
Preliminary investigation and isolation of the antidiabetic principles of combretum dolichopetalum root
Protective effects of radix angelicae dahuricae extract on cerebral ischemic injury on rat
Safety and bioefficacy evaluation of the essential oil from pogostemon cablin (blanco) benth. (lamiaceae) against aedes aegypti
Saffron extract inhibits the glutamatergic synaptic transmittion in rat cortical neurons
Screening extracts of south australian marine sponges for efficacy against breast cancer stem cells
Significance of p-glycoprotein induction by kavain and kaempferol compared to traditional p-gp inducers.
Synergistic study of salvia miltiorrhizae radix & rhizoma (danshen) and notoginseng radix et rhizoma (sanqi) combinations for inhibiting nitric oxide production in raw 264.7 cells
The additive antifungal effect of the combination between kaffir lime oil (citrus hystrix dc.) and fennel oil (foeniculum vulgare mill.) against pityrosporum ovale
The effect of asetic ethyl fraction of ethanol extract of pasak bumi (eurycoma longifolia jack) on p53 expression in sd mice induced by dmba ((dimetil benzo(a)anthrasen)
Toxicological standardization of heavy metals and microbial contamination haematinic herbal formulations marketed in india
Traditional medicine therapy as an alternative cure for hiv/aids among geriatric persons in sub-saharan african countries
Unravelling the immunomodulatory role of malaysian tualang honey
Valerian officinalis l. root extract: no evidence for clinically relevant interactions
Pharmacoepidemiology and Health Technology Assessment
A study of extemporaneous compounding in a sample of australian public hospitals
Analysis and evaluation of the safety usage of strontium renelate at a regional teaching hospital of southern taiwan
Comparison of the 8-item morisky medication adherence scale before and after a pharmaceutical care intervention and its association to blood pressure control of chronically hypertensive elderly patients- implementation of a phase-by-phase care program
Criteria of drug risk management decision in thailand
Current status of adverse drug reactions monitoring centers in pharmacovigilance programme of india
Effect of drug transporters on hepatic distribution and pharmacokinetics of mefenamic acid and its acyl-conjugated metabolites
Effects of polypharmacy on adverse drug reactions among geriatric outpatients at a tertiary care hospital in karachi, a prospective cohort study
Elimination of phenytoin, phenobarbital and valproic acid in patients with head injury
Impact of educational intervention for improving malaysian parents
Impact of patient education on health-related quality of life (hrqol) of diabetic foot ulcer patients- a randomized controlled study
In vitro intestinal models for predicting herb-drug interactions during oral drug delivery
Indonesian tuberculosis patients' quality of life during three months of tuberculosis treatment: primary health care perspective
Influence of storage conditions on the potency of norfloxacin tablets stored in hospital and community pharmacies in different regions of kerala.
Investigating the patterns of psychotropic medicines use in a mental health centre
Medication exposure assessment in australian prospective cohort studies
Nat2 haplotype distribution in a nigerian population
Participation of women, children and elderly in the clinical trials: australian prospective view
Photodegradation of oseltamivir (tamiflutm) in aqueous solution
Potential drug-drug interactions in hiv-infected children on highly active antiretroviral therapy in lagos, nigeria
Prevalence and factors associated with statin use in geriatric oncology
Study of antibiotic consumption pattern in acute exacerbation of copd
The use of geographic information system to map hepatitis b cases and the midication use in treatment in the southeastern region of brazil
To design a validate questionnaire for evaluating the quality of pharmacist-managed warfarin clinic service
To study the proposal for setting up a day care and research centre for diabetes
Utilization of total parenteral nutrition in a south indian tertiary care hospital
Pharmacokinetics (PK), Pharmacodynamics (PD) and Systems Pharmacology
A new empirical modelling approach for quantifying bacterial killing and regrowth in in vitro static time-kill studies
Abcb1 and abcg2 mediate transport of abacavir and hinder its passage across the placenta
Absorption enhancing mechanisms of gemini surfactants on the intestinal absorption of poorly absorbable drugs in rats
Artemisinin-based combination therapy (act) and acceptability in nigeria in the management of malaria in children aged 0-5 years
Carbon monoxide bound red blood cells protect the expression of hepatic cytochrome p450 after resuscitation from hemorrhagic shock via inactivation of kupffer cells
Cis/trans isomerism is an important determinant of clearance processes for two pairs of 1,2,4-trioxolanes.
Convolution as a tool for generic product development
Cranberry significantly reduced the absorption of warfarin in rats
Cyp2d6*10 polymorphisms on tamoxifen metabolism in breast cancer patients
Delivering crushed paracetamol tablets using thickened fluids: does it alter the pharmacokinetics?
Differential binding patterns of lipophilic compounds to fatty acid binding proteins
Dose-ranging pharmacokinetic and pharmacodynamic assessment of oxytocin after pulmonary administration of a dry powder formulation to postpartum sheep.
Dysfunction of a urate exporter abcg2 increases serum uric acid by decreased intestinal urate excretion
Effect of albumin on transthyretin disposition and tissue deposition in vivo
Effect of cyclosporine a on hepato-biliary disposition of etoposide in an isolated perfused rat liver model
Effect of mdma on the pharmacokinetic of tramadol
Enhanced brain delivery of bioactive peptide drugs via intranasal administration with cell-penetrating peptides
Enhanced dasatinib absorption in healthy volunteers with rabeprazole-induced hypochlorhydria using betaine hcl (bhcl)
Ethanol effects on apparent solubility of poorly soluble drugs in simulated gastric fluid.
Evaluation of the deacylation-reacylation metabolic cycle responsible for lymphatic transport of a triglyceride-mimetic prodrug
Expression and function of a peptide transporter pept2 in alveolar epithelial cells in culture
Green tea elevated the blood level of indoxyl sulfate, a nephro - cardiovascular toxin, in renal failure rats
Health promotion in cardiovascular disease prevention and self-management: increasing patient awareness of modifiable cardiovascular risk factors. pharmacy student honours project
Identification of anti-parasitic drug targets with untargeted metabolomics
Inhibition of basolateral efflux transporter causes drug induced bile acids-dependent hepatotoxicity
Involvement of caveolin-1 tyrosine 14 and src tyrosine 419 phosphorylation levels in intrinsic p-glycoprotein transport function at human blood-brain barrier
Modeling of rifampicin-induced cyp3a4 activation dynamics for the prediction of clinical drug-drug interactions
Optimizing the therapeutic activity of sphingosine-1-phosphate receptor modulators through lymph targeted delivery
Pharmacokinetic study of enclosed adenosine diphosphate and outer lipid component after the administration of h12-(adp)-liposome as a synthetic platelet substitute
Pharmacokinetics of linezolid in burn and non-burn rabbits
Pharmacokinetics/pharmacodynamics of lithium in paediatric patients with bipolar disorder: implications for selection of dosage regimens
Phase i, randomized, open-label study evaluating the pharmacokinetics, pharmacodynamics and safety profile of repeated five-day-dose of intravenous rabeprazole sodium in healthy chinese volunteers
Physiologically based pharmacokinetic (pbpk) modeling for the prediction of drug-drug interactions mediated by hepatic uptake transporters, oatps
Physiologically based pharmacokinetic (pbpk) modeling to predict the drug-drug interaction between cerivastatin and cyclosporin a
Population pharmacokinetics of orally administered mefloquine in healthy volunteers and patients with uncomplicated plasmodium falciparum malaria
Potential modulation on bcrp and mrp 4 by onion: in vivo and ex-vivo studies of onion-methotrexate interaction
Prediction of oral absorption of cinnarizine under fasted and fed state conditions
Prediction of the clinical risk of drug-induced cholestatic liver injury from in vitro rat sandwich cultured hepatocytes assay.
Radical scavenging activity of benzbromarone as a novel property in vitro
Role of p-glycoprotein in the brain penetration and brain pharmacodynamic activity of the mek inhibitor cobimetinib
Safety and pharmacokinetic studies of hepatically-metabolized and
Simultaneous determination of erlotinib and its major metabolites in human plasma using an isocratic liquid chromatography tandem mass spectrometry
Simultaneous lc-ms/ms analysis of the plasma concentrations of a cocktail of 5 cytochrome p450 substrate drugs and their metabolites
Targeted inhibition of atp-bing cassette transporter a1 protein degradation promotes reverse cholesterol transport and reduces atherosclerosis in mice
The effects of gastric ph on the pharmacokinetics of atazanavir in healthy volunteers
The impact of intravenous sbe7-
The rheumatoid arthritis susceptibility polymorphism ptpn22 c1858t is not associated with leflunomide response or toxicity.
Transplacental pharmacokinetics of lamivudine is not affected by abc drug efflux transporters
Pharmacology
Anticholinergic burden assessed using australian general practice electronic records
Can chronic disease patient management be readily shared between pharmacists and general practitioners?
Development of fret based probe to detect conformational change of vla4 for visualizing cell adhesion
Evaluation of hypoglycaemic, hypolipidemic and nephroprotective potential of hedychium spicatum in stz induced diabetic rats.
Human skin irritation test of royal jelly cream using patch-test method
Impacts of opioid addiction on male reproductive system; a randomized controlled trials (rct) on 40 rats
L-ornithin-l-aspartate overexpresses bax levels to illustrate hepaptoprotective action: an in vitro and in vivo investigation
Medication regimen complexity, polypharmacy and hospital discharge destination: a prospective cohort study
Microencapsulated bioadhesive vaginal gel (mbvg) of boehmeria virgata ethanol extract from south sulawesi indonesia against hela cell line
Molecular imaging monitoring of poly(ethylene glycol) conjugated islets for evaluation of islet graft rejection
Multi-functional approach to combat experimental acute neurotoxicity induced by organophosphate pesticide
Nhba exerts sedative and hypnotic effects in sodium pentobarbital-treated mice
Nicotine deteriorates alcohol dependence through alteration of acetylcholinesterase activity: a conditioned place preference approach
Polymyxins accumulate in rat kidney tubular cells and induce apoptosis
Preclinical study: hepatoprotective effects of paliasa capsule on paracetamol-induced liver damage in rats
Preventing the blood-brain barrier disruptive effects of lipopolysaccharide with polymyxin analogues
Resveratrol attenuates inflammation and oxidative stress in carbon black nanoparticles-treated a549 human lung epithelial cells
Reversal of chronic fatigue induced alterations by sesamol in mice: evidence for involvement of oxidative stress and inflammatory pathway
Reversal of liver fibrosis in chronic murine schistosomiasis mansoni by safironil/praziquantel
Species difference in stereoselective oxidation of carvedilol enantiomers in rat and human
The review of reported adverse drug reactions in a local health facility pharmacy student honours project
The xanthine derivative kmup-1 stimulates osteoblastogenesis through activating the bmp/runx-2 signaling pathway
Yhp-743, a noval parp1/2 inhibitor for treatment of human triple-negative breast cancer with brca deficiency
Regulatory Sciences - BCS and Biowaivers
In silico pk simulations to explore the risks of inappropriate biowaiver decisions for bcs i and iii efflux transport substrates
Regulatory Sciences - Clinical Bridging Studies
Harmonization-by-doing: overcoming regulatory barriers
Predicting which anti-epileptic drugs will cause hla-associated drug hypersensitivity using the biopharmaceutical drug disposition classification system (bddcs)
Regulatory Sciences - Dissolution/In vitro drug release
Comparing the solubility of three poorly soluble apis in conventional and new biorelevant media with human intestinal fluid
Dissolution enhancement of celecoxib solid dispersion using spray drying and precipitation with antisolvent
Dissolution profile comparison of linezolid tablets by model independent approach using similarity factor method and establishing the product quality performance.
Drug release from magnesium orthopaedic implants
Factors influencing release from enteric coated aspirin tablets
Influence of hpmc on dissolution and supersaturation characteristics
Predicting dosage form-dependent food effects with biorelevant multi-compartmental dissolution tests: case example nifedipine
Translational Research and Individualized Medicines
Association between cardiovascular autonomic neuropathy and peripheral sympathetic neuropathy in rheumatoid arthritis and ankylosing spondylitis patients
Development and implementation of guidelines for pharmacist only medicine (phom) in selected community pharmacy in ras al khaimah, uae.
Preclinical safety assessment of substrates for human p-glycoprotein: bioinformatics-assisted selection of
Prevention and disease modification of parkinson's disease by drug reprofiling
System-to-system research mode in diabetic nephropathy diagnosis and drug efficacy evaluation
The association between ugt1a1*28 and survival after irinotecan chemotherapy: a collaborative systematic review and meta-analysis
Thiopurine s-methyltransferase (tpmt) phenotypes in the nigerian population
Treating early rheumatoid arthritis to target using protocolized escalation of disease-modifying antirheumatoid drugs: the influence of protocol violation on long term clinical and functional outcome
Validated lc-ms/ms method for the determination - o6-methylguanine in cancer patients