Orally formulated bifidobacteria and lactobacilli decrease the bioavailability of the bile acid, mkc, in healthy and diabetic rats

• In: Posters C - Drug Design and Discovery
• At: PSWC, Melbourne (Australia) (2014)
• Type: Poster
• Poster code: PC-007
• By: AL-SALAMI, Hani (Curtin Health Innovation Research Institute, Biosciences Research Precinct, Perth, Australia)
• Co-author(s): Tucker, Ian (Otago School of Pharmacy, Dunedin, New Zealand)
  Fawcett, Paul (Otago School of Pharmacy, Dunedin, New Zealand)
  Butt, Grant (Otago Faculty of Medicine, Dunedin, New Zealand)
  Mikov, Momir (Otago School of Pharmacy, Dunedin, New Zealand)
  
• Abstract:

  Aim. To report the influence of pretreatment with probiotics on the pharmacokinetics of MKC in a rat model of type 1 diabetes (T1D). Methods. Male Wistar rats (weight 350±50g) were randomly allocated into 8 equal groups, 4 of which were treated with alloxan iv 30mg/kg to induce diabetes. Group 1 was healthy (control) and group 2 was diabetic...

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