Safety and pharmacokinetic studies of hepatically-metabolized and

• In: Posters G - Pharmacokinetics (PK), Pharmacodynamics (PD) and Systems Pharmacology
• At: PSWC, Melbourne (Australia) (2014)
• Type: Poster
• Poster code: PG-
• By: TAGUCHI, Kazuaki (Sojo University, Faculty of Pharmaceutical Sciences, Kumamoto, Japan)
• Co-author(s): Sakai, Hiromi (Department of Chemistry, Nara Medical University, Kashihara, Japan)
  Maruyama, Toru (Kumamoto university, Kumamoto, Japan)
  Otagiri, Masaki (Sojo University, Kumamoto, Japan)
  
• Abstract:

  [Background] The hemoglobin-vesicle (HbV) is a cellular type hemoglobin based oxygen carrier. Our previous studies demonstrated that the liver is strongly associated with the metabolism and excretion of HbV. [Aims] The aim of this study was to determine whether the changes of liver function affect the metabolic and excretion of HbV in rats with..

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