Therapeutic impact of human serum albumin-thioredoxin fusion protein, long-acting anti-oxidative and anti-inflammatory modulator, against acetaminophen-induced acute hepatopathy

• In: Posters C - Drug Design and Discovery
• At: PSWC, Melbourne (Australia) (2014)
• Type: Poster
• Poster code: PC-039
• By: WATANABE, Hiroshi (School of Pharmacy, Kumamoto University, Biopharmaceutics, Kumamoto, Japan)
• Co-author(s): Tanaka, Ryota (School of Pharmacy, Kumamoto University, Kumamoto, Japan)
  Maeda, Hitoshi (School of Pharmacy, Kumamoto University, Kumamoto, Japan)
  Kodama, Azusa (School of Pharmacy, Kumamoto University, Kumamoto, Japan)
  Taguchi, Kazuaki (Faculty of Pharmaceutical Sciences, Sojo University, Kumamoto, Japan)
  Ishima, Yu (School of Pharmacy, Kumamoto University, Kumamoto, Japan)
  Otagiri, Masaki (Faculty of Pharmaceutical Sciences, Sojo University, Kumamoto, Japan)
  Maruyama, Toru (School of Pharmacy, Kumamoto University, Kumamoto, Japan)
  
• Abstract:

  [Purpose] Acetaminophen (APAP) overdose is a major cause of acute liver failure. Although N-acetylcysteine (NAC) is used to treat patients with APAP overdose due to the accumulating evidences that oxidative stress plays an important role in the pathogenesis of APAP-induced hepatitis, the therapeutic efficacy of NAC is not sufficient. We previously ..

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