Investigating the structural and thermodynamic basis of substrate selectivities of human cytochrome p450 enzymes: a molecular dynamics study

• In: SUBMITTED ORALS on Wednesday, 16 April 2014, 14:00-15:30
• At: PSWC, Melbourne (Australia) (2014)
• Type: Presentation
• By: NAIR, Pramod (Flinders University of South Australia, Clinical Pharmacology, Adelaide, Australia)
• Co-author(s): Miners, John O. (Flinders University of South Australia, Adelaide, Australia)
  
• Abstract:

  Enzymes of the cytochrome P450 (CYP) superfamily are responsible for the metabolism of a myriad of compounds that include drugs, non-drug xenobiotics (e.g. environmental chemicals), and endogenous compounds. The individual P450 enzymes exhibit characteristic substrate and inhibitor selectivities, and enzyme activities are variably affected by age, ..

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