Development of fret based probe to detect conformational change of vla4 for visualizing cell adhesion

• In: Posters H - Pharmacology
• At: PSWC, Melbourne (Australia) (2014)
• Type: Poster
• Poster code: PH-011
• By: HIGUCHI, Yuriko (Kyoto University, The center for the promotion of interdisciplinary education and research: C-PIER, Kyoto, Japan)
• Co-author(s): Sugihara, Yuka (Kyoto University, Kyoto, Japan)
  Yamashita, Fumiyoshi (Kyoto University, Kyoto, Japan)
  Hashida, Mitsuru (Kyoto University, Kyoto, Japan)
  
• Abstract:

  I. Background
  Very late antigen-4 (VLA4, integrin α4β1), which expresses on leucocyte, T cell or mesenchymal stem cells, regulates their homing and tissue selective adhesion to endothelial cells. In these processes, integrin changed its structure in the bent or extended conformation. During a bent conformation, integrin can bind with VCAM1..

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