The xanthine derivative kmup-1 stimulates osteoblastogenesis through activating the bmp/runx-2 signaling pathway

• In: Posters H - Pharmacology
• At: PSWC, Melbourne (Australia) (2014)
• Type: Poster
• Poster code: PH-004
• By: LIOU, Shu-Fen (Chia-Nan University of Pharmacy and Science, Department of Pharmacy, Tainan, China Taiwan)
• Co-author(s): Chen, Chiu-Lan (Chia-Nan University of Pharmacy and Science, Tainan, China Taiwan)
  Shih, Mei-Fen (Chia-Nan University of Pharmacy and Science, Tainan, China Taiwan)
  
• Abstract:

  Background: KMUP-1 is a xanthine derivative with inhibitory activities on the phosphodiesterase (PDE) 3,4 and 5 isoenzymes to suppress the degradation of cyclic AMP and cyclic GMP. However, whether KMUP-1 has any effect on osteoblast differentiation is still unclear.
  Aims:This study aimed to investigate the effect of KMUP-1 on differentiation of..

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