Development of a novel self-dissolving microneedle array of alendronate, a nitrogen-containing bisphosphonate

• In: SUBMITTED ORALS on Wednesday, 16 April 2014, 13:00-14:15
• At: PSWC, Melbourne (Australia) (2014)
• Type: Presentation
• By: KUSAMORI, Kosuke (Kyoto Pharmaceutical University, Biopharmaceutics, Kyoto, Japan)
• Co-author(s): Katsumi, Hidemasa (Kyoto Pharmaceutical University, Kyoto, Japan)
  Liu, Shu (Kyoto Pharmaceutical University, Kyoto, Japan)
  Tanaka, Yutaro (Kyoto Pharmaceutical University, Kyoto, Japan)
  Hitomi, Kaori (Kyoto Pharmaceutical University, Kyoto, Japan)
  Hayashi, Rie (Kyoto Pharmaceutical University, Kyoto, Japan)
  Hirai, Yuka (Kyoto Pharmaceutical University, Kyoto, Japan)
  Sakane, Toshiyasu (Kyoto Pharmaceutical University, Kyoto, Japan)
  Yamamoto, Akira (Kyoto Pharmaceutical University, Kyoto, Japan)
  
• Abstract:

  Alendronate is a nitrogen-containing bisphosphonate that is widely used for the treatment of osteoporosis. However, oral delivery of alendronate is strictly limited by its poor absorption across the intestinal epithelium, because alendronate is highly polar and hydrophilic. In addition, oral administration of alendronate can cause gastrointestinal ..

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