Investigating the effects of cholesterol on non-lamellar liquid crystalline nanoparticles as potential drug delivery systems

• In: Posters D - Formulation Design and Pharmaceutical Technology
• At: PSWC, Melbourne (Australia) (2014)
• Type: Poster
• Poster code: PD-063
• By: DONG, Yao-Da (Charlie) (Monash University, Drug Delievery, Disposition and Dynamics, Parkville, Australia)
• Co-author(s): Lee, Kelvin (Department of Pharmacology and Pharmacy, the University of Hong Kong, Hong kong, China - Hong-Kong)
  Tey, Nadine (Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Scie, Parkville, Australia)
  Segal, David (Chemical Biology Division The Walter and Eliza Hall Institute of Medical Researc, Parkville, Australia)
  Boyd, Ben (Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Scie, Parkville, Australia)
  
• Abstract:

  Background: Cholesterol reduces the lipid bilayer fluidity of phospholipid-based liposomes to allow for effective liposome active encapsulation. As such, cholesterol is considered an essential component of liposome-based drug delivery systems. Non-lamellar lipid-based liquid crystalline nanoparticles such as cubosomes have complex internal

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