Menu
  • Join
  • Login
  • Contact
 

Search abstracts / presentations


Design, synthesis and antitumor activity research of psammaplin a derivatives

  • In: Posters C - Drug Design and Discovery
  • At: PSWC, Melbourne (Australia) (2014)
  • Type: Poster
  • Poster code: PC-042
  • By: LIU, Dan (Shenyang Pharmaceutical University, Shenyang, China)
  • Co-author(s): Wen, Jiachen (Shenyang Pharmaceutical University, Shenyang, China)
    Jiang, Tao (Shenyang Pharmaceutical University, Shenyang, China)
    Zhao, Linxiang (Shenyang Pharmaceutical University, Shenyang, China)
  • Abstract:

    Background: Histone deacetylases (HDACs) and DNA methyltransferase (DNMT) are the key enzymes for epigenetics alterations. The marine natural product Psammaplin A (PSA), which was reported to inhibit HDACs (IC50 = 4.2 nM) and DNMTs (IC50 = 18.6 nM) was taken as leading compound. A series of PSA derivatives were designed and synthesized, the..

  • The access to the whole abstract and if available the presentation file is available to FIP members and to congress participants of that specific congress. Please login
Last update 28 September 2023

FIP Congresses