Influence of lactose, polyvinylpyrrolidone and polyethyleneglycol in mucoadhesive buccal tablets of chlorexidine diacetate

• In: SIG Bioavailability / Bioequivalence - Poster Session
• At: Salvadore (Brazil) (2006)
• Type: Poster
• Poster code: BB-P-004
• By: KANEKO, Telma Mary (São Paulo University, SÃo Paulo, Brazil)
• Co-author(s): Ferrarini, Marcio (São Paulo University, Brazil)
  Baby, Andre Rolim (São Paulo University, Brazil)
  Honda, Akimi Mori (Biolab Sanus Farmacêutica Ltda, SÃO PAULO, Brazil)
  Consiglieri, Vladi Olga (São Paulo University, Brazil)
  Velasco, Maria Valéria Robles (São Paulo University, Brazil)
  Taqueda, Maria Elena (São Paulo University, SÃO PAULO, Brazil)
  Kaneko, Telma Mary (São Paulo University, SÃO PAULO, Brazil)
  
• Abstract:

  This investigation deals with the development of buccal adhesive tablets formulations of chlorhexidine diacetate. An ideal buccal delivery system should adhere in the oral cavity and release the drug in unidirectional way toward to the mucosa in a controlled- or sustained-release approach. Seventeen formulations with 5 mg of the active ingredient..

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