The new pH sensitive polycation improves the transfection activity of R8-modified lipid nanoparticles by facilitating siRNA condensation

• In: SIG Posters
• At: Amsterdam (the Netherlands) (2012)
• Type: Poster
• Poster code: FDP-P-28
• By: TORIYABE, Naoyuki (Hokkaido University, Faculty of Pharmaceutical Science, Sapporo, Japan)
• Co-author(s): Hayashio, Y. (Hokkaido University, Sapporo, Japan)
  Akita, H. (Hokkaido University, Sapporo, Japan)
  Harashima, H. (Hokkaido University, Sapporo, Japan)
  
• Abstract:

  
  ?. Background
  We previously developed octaarginine (R8) and GALA, as a pH-sensitive fusogenic peptide modified a lipid Double-lamellar Multifunctional Envelope-type Nanoparticles Device (R8/GALA-D-MEND) for siRNA delivery. Herein, we report whether a new pH sensitive polycation (pHSP), as a siRNA condensed polycation in response to pH difference,

  ..

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