New applications of hot-melt extrusion for uniform distribution of very low dose drugs

• In: SIG Posters
• At: Amsterdam (the Netherlands) (2012)
• Type: Poster
• Poster code: FDP-P-15
• By: LEE, Beom-Jin (Ajou University, College of Pharmacy, Suwon, South-Korea)
• Co-author(s): Park, J.B. (College of Pharmacy, Kangwon National University, Chuncheon, South-Korea)
  Choung, S.Y. (College of Pharmacy, Kyunghee University, Seoul, South-Korea)
  Cheong, J.H. (College of Pharmacy Sahm Yook University, Seoul, South-Korea)
  Chun, I.K. (College of Pharmacy, Dongdujk Women’s University, Seoul, South-Korea)
  
• Abstract:

  The aim of this study was to prepare uniformly and homogeneously distributed dosage form of very low dose drugs using twin screw hot-melt extrusion (HME) and investigate the distribution of API using instrumental analysis. Very low amount of coumarin-6, a fluorescence dye was chosen for visual images using confocal laser scanning microscope

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