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Interaction of quinolines with the amino acids tryptophan, tyrosine and phenylalanine
- In: Posters
- At: Amsterdam (the Netherlands) (2012)
- Type: Poster
- Poster code: HPS-P-052
- By: ISLAHUDIN, Farida (University of Nottingham, Nottingham, United Kingdom)
- Co-author(s): Pleass, R.J. (University of Liverpool, Liverpool School of Tropical Medicine, Liverpool, United Kingdom)
Avery, S.V. (University of Nottingham, Nottingham, United Kingdom)
Ting, K.N. (University of Nottingham Malaysia Campus, Semenyih 43500, Malaysia) - Abstract:
The efficacy of the quinoline anti-malarials are marred by resistance and inter-individual patient responses. There is also a lack of understanding of its mechanism of action. A recent study using yeast model revealed that quinine competed with tryptophan for uptake via the same transporter, causing tryptophan starvation. Tyrosine uptake was also
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Last update 23 September 2026