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Molecular basis of fruit juice interactions affecting bioavailability
- In: S3 - Natural Products as therapeutic modulators on Tuesday, 2 September 2008, 9:00-12:00
- At: Basel (Switzerland) (2008)
- Type: Presentation
- By: BAILEY, David (University of Western Ontario, London, Ontario, Canada)
- Abstract:
The first food reported to decrease drug metabolism in humans was grapefruit juice. This finding was serendipitous and resulted from a drug interaction study with ethanol in which this juice had been a taste-masking agent. Grapefruit juice tripled the oral bioavailability of the antihypertensive medication, felodipine. It acted through
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