Synthesis and pharmcological profiles of the anticholinergic agent, n-alkyl phencynonate and the optical isomers

• In: Medicinal Chemistry - Posters
• At: Istanbul (Turkey) (2009)
• Type: Poster
• Poster code: MC-P-014
• By: LIU, He (Beijing Institute of Pharmacology and Toxicology, Beijing, China)
• Abstract:

  The new anticholinergic agents,N-alkyl-9a-(3-Azabicyclo[3,3,1]nonanyl)-2
  
  '-cyclopentyl-2'-hydroxy-2'-phenylacetate (CPG),were synthesized and the enantiomers were obtained by the optical resolution
  
  of racemates with the chiral host N-p-toluenesulfonylglutamic acid. Optical pure isomers
  
  were also effective diastereoselective synthesized using..

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