In vitro and in silico analysis of uptake of sialyl LewisX mimic-decorated liposomes in inflamed endothelial cells

• In: Poster Presentation
• At: Stockholm (Sweden) (2017)
• Type: Poster
• Poster code: P-B-015-Tuesday
• By: HASHIDA, Mitsuru (Kyoto University, Graduate School of Pharmaceutical Sciences, Kyoto, Japan)
• Co-author(s): Mitsuru Hashida: Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan
  Chanikarn Chantarasrivong: Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan
  Akiharu Ueki: Department of Applied BioorganicChemistry, Gifu University, Gifu, Japan
  Shinya Nakamura: Faculty of Pharmacy, Kindai University, Osaka, Japan
  Isao Nakanishi: Faculty of Pharmacy, Kindai University, Osaka, Japan
  Yuriko Higuchi: Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan
  Hiromune Ando: Department of Applied BioorganicChemistry, Gifu University, Gifu, Japan
  Fumiyoshi Yamashita: Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan
  Makoto Kiso: Department of Applied BioorganicChemistry, Gifu University, Gifu, Japan
  
• Abstract:

  Backgrounds

  Sialyl LewisX (sLeX) is a natural ligand of E-selectin overexpressed in inflamed endothelium. sLeX is a potential targeting ligand for E-selectin-mediated drug delivery, but the synthesis of sLeX is complicated.

  Aims

  The aims of this study are (1) to develop liposomes bearing structurally simplified novel sLeX analogs, (2) to characterize

  ..

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