Development of long-lasting stapled peptides targeting BIG3-PHB2 interaction in breast cancer cells

• In: Poster Presentation
• At: Stockholm (Sweden) (2017)
• Type: Poster
• Poster code: P-A-033-Tuesday
• By: OTAKA, Akira (Insutitute of Biomedical Sciences, Tokushima University, Japan, Tokushima, Japan)
• Co-author(s): Akira Otaka: Insutitute of Biomedical Sciences, Tokushima University, Tokushima, Japan
  Keisuke Aihara: Insutitute of Biomedical Sciences, Tokushima University, Tokushima, Japan
  Tetsuro Yoshimaru: Institute for Genome Research, Tokushima University, Tokushima, Japan
  Akira Shigenaga: Insutitute of Biomedical Sciences, Tokushima University, Tokushima, Japan
  Toyomasa Katagiri: Institute for Genome Research, Tokushima University, Tokushima, Japan
  
• Abstract:

  Backgrounds

  A novel estrogen signaling regulator: brefeldin A-inhibited guanine nucleotide-exchange protein 3 (BIG3), which is overexpressed in a majority of breast cancers. BIG3 captures prohibitin 2 (PHB2) in the cytoplasm of cancer cells and inhibits the suppression of ERα signaling pathways. Based on these findings, ERα activity-regulator..

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