Synthetic studies toward a quinolinone alkaloid aspoquinolone A possessing potent antiproliferative activity

• In: Poster Presentation
• At: Stockholm (Sweden) (2017)
• Type: Poster
• Poster code: P-A-044-Monday
• By: TSUBUKI, Masayoshi (Hoshi University, Tokyo, Japan)
• Co-author(s): Masayoshi Tsubuki: Hoshi University, Tokyo, Japan
  Takumi Hosozawa: Rikkyo University, Tokyo, Japan
  Hiromasa Yokoe: Hoshi University, Tokyo, Japan
  Hiroaki Tokiwa: Rikkyo University, Tokyo, Japan
  
• Abstract:

  Backgrounds

  Recently, aspoquinolone A (1), a quinolinone alkaloid, has been isolated from Aspergillus nidulans (HKI 0410) by Hertweck et al. and exhibits high cytotoxicity against L-929 mouse fibroblast cell lines (GI50 10.6 μg ml-1) and good antiproliferative effects on human leukemia cell line K-562 (GI50 17.8 μg ml-1). The structural features of ..

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