Relationship of P450 2C9 genetic polymorphisms in Chinese and the pharmacokinetics of tolbutamide

• In: SIG Bioavailability/Bioequivalence - Posters
• At: Beijing (China) (2007)
• Type: Poster
• Poster code: BB-P-005
• By: CHEN, Kun (Chinese PLA General Hospital, Beijing, China)
• Co-author(s): Wang, Rui (Chinese PLA General Hospital, BEIJING, China)
  Ji, Xiaolong (Chinese PLA General Hospital, BEIJING, China)
  
• Abstract:

  Abstract AIM: To study the relationship of P450 2C9 genetic polymorphisms and the pharmacokinetics of tolbutamide in Chinese. METHODS: P450 2C9 genotype was determined by oligonucleotide microarray. Using tolbutamide as a probe of P450 2C9 activity, P450 2C9 phenotype in 63 healthy individuals expressing the P450 2C9*1/*1, *1/*3 and *3/*3

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