Optimization of poorly compactable drug tablets manufactured by direct compression using the mixture experimental design

• In: G19 - Industrial Pharmacy Education and practice on Monday, 28 August 2006, 9:00-12:00
• At: Salvadore (Brazil) (2006)
• Type: Presentations + Posters
• By: MARTINELLO, Tiago (Universidade de São Paulo, São Paulo, Brazil)
• Co-author(s): Kaneko, Telma Mary (Universidade de São Paulo, São Paulo, Brazil)
  Velasco, Maria Valéria Robles (Universidade de São Paulo, São Paulo, Brazil)
  Takeda, Maria Elena Santos (Universidade de São Paulo, São Paulo, Brazil)
  Consiglieri, Vladi Olga (Universidade de São Paulo, São Paulo, Brazil)
  
• Abstract:

  The poor flowability and bad compressibility characteristics of paracetamol are well known. As a result, the production of paracetamol tablets is almost exclusively by wet granulation, a disadvantageous method when compared to direct compression. The development of a new tablet formulation is still based on a large number of experiments and often

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