Rapid expansion of supercritical solutions (ress) as a tool for simultaneous cocrystallization and micronization of poorly soluble drugs: (i) cocrystal production and identification

• In: Posters D - Formulation Design and Pharmaceutical Technology
• At: PSWC, Melbourne (Australia) (2014)
• Type: Poster
• Poster code: PD-014
• By: MUELLERS, Katrin (Eberhard Karls University Tuebingen, Pharmaceutical Technology and Biopharmacy, Tuebingen, Germany)
• Co-author(s): Wahl, Martin (Eberhard Karls University Tuebingen, Tuebingen, Germany)
  
• Abstract:

  I Background
  Cocrystals are usually prepared by slow crystallization from organic solvents, which might bear the disadvantage of crystallizing the pure components. In the RESS process, a supercritical solution is depressurized rapidly to atmospheric conditions, thus very limited time for nucleation and crystal growth is available. Micron particles ..

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