Improved oral bioavailability and reduced nephrotoxicity of self-emulsifying formulation of cyclosporin a in combination with antioxidant following oral administration

• In: Posters D - Formulation Design and Pharmaceutical Technology
• At: PSWC, Melbourne (Australia) (2014)
• Type: Poster
• Poster code: PD-005
• By: JAIN, Sanyog (National Institute of Pharmaceutical Education and Research (NIPER), Department of Pharmaceutics, Sas nagar, India)
• Co-author(s): Kambam, Sindu (National Institute of Pharmaceutical Education and Research (NIPER), Sas nagar, India)
  Jain, Amit Kumar (National Institute of Pharmaceutical Education and Research (NIPER), Sas nagar, India)
  
• Abstract:

  Background: Cyclosporin A(CyA) is commercially available as self-emulsifying drug delivery system (SEDDS) (Neoral^®, Bioral^®) yet drug-induced nephrotoxicity is the major challenge.
  Aim: SEDDS of CyA in combination with an antioxidant (Vitamin E TPGS) were developed with the aim to improve bioavailability and reduce nephrotoxicity.
  Methods:..

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