A validated method high-performance liquid chromatography tandem mass spectrometry (hplc-ms-ms) for determination of isoniazid and acetylisoniazid in plasma human to determine acetylator phenotype

• In: SIG Bioavailability / Bioequivalence - Poster Session
• At: Salvadore (Brazil) (2006)
• Type: Poster
• Poster code: BB-P-007
• By: GONCALVES, J.C. (Fac Farmácia-UFRJ, Rio De Janeiro, Brazil)
• Co-author(s): Neves de Miranda, Claudia (Fac Farmácia-UFRJ, RIO DE JANEIRO, Brazil)
  
• Abstract:

  To establish a useful method for acetylator phenotypication and therapeutic drug monitoring of patients receiving isoniazid a rapid and sensitive method using high-performance liquid chromatography tandem mass spectrometry (HPLC-MS-MS) was developed and evaluated for simultaneous quantitative determination of isoniazid and its major metabolite,..

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