Microwave-assisted forced degradation of duloxetine

• In: SIG Posters
• At: Amsterdam (the Netherlands) (2012)
• Type: Poster
• Poster code: ASP-P-05
• By: GOMES, Patrícia (Centro Universitário Franciscano, Programa de Pós-Graduação em Nanociências, Santa Maria, Brazil)
• Co-author(s): Müller, A.L.H. (Universidade Federal de Santa Maria, Santa Maria-RS, Brazil)
  Flores, E.M.M. (Universidade Federal de Santa Maria, Santa Maria-RS, Brazil)
  Da Silva, U.F. (Universidade Federal de Santa Maria, Santa Maria-RS, Brazil)
  Da Silva, F.E.B. (Universidade Federal do Pampa, Uruguaiana-RS, Brazil)
  Wingert, N.R. (Universidade Federal do Rio Grande do Sul, Porto Alegre-RS, Brazil)
  Schapoval, E.E. (Universidade Federal do Rio Grande do Sul, Porto Alegre-RS, Brazil)
  Steppe, M. (Universidade Federal do Rio Grande do Sul, Porto Alegre-RS, Brazil)
  
• Abstract:

  Background: Forced degradation or stress studies of drug substances play an integral role in the development of pharmaceutical products. Duloxetine hydrochloride is unstable and degrades when exposed to acidic conditions. Aims: The aim of this study was to expose the duloxetine (DLX) pharmaceutical dosage form to acid hydrolysis using

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