Nitrofurantoin permeability through Caco-2 cells: a parameter to develop new oral 5-nitro-heterocyclic compounds with potential activity against Multirresistant Staphylococcus aureus

• In: SIG Posters
• At: Amsterdam (the Netherlands) (2012)
• Type: Poster
• Poster code: DDD-P-01
• By: BALLERINI FERNANDES, Mariane (University of São Paulo, Pharmacy, São Paulo, Brazil)
• Co-author(s): Gonçalves, J.E. (University of São Paulo, São Paulo, Brazil)
  Costa Tavares, L. (University of São Paulo, São Paulo, Brazil)
  Storpirtis, S. (University of São Paulo, São Paulo, Brazil)
  
• Abstract:

  New 5-nitro-heterocyclic compounds have shown potential
  in vitro
  activity against multidrug-resistant
  S. aureus
  , being important and necessary the oral bioavailability evaluation as next stage in the development of a new drug. Nitrofurantoin, a 5-nitro-heterocyclic agent used in urinary infections, presents high oral bioavailability (?90%). This

  ..

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