Different inhibitory effects of angiotensin II receptor blockers on cytochrome P4502C9 dependent formation of epoxyeicosatrienoic acids from arachidonic acid

• In: SIG Posters
• At: Amsterdam (the Netherlands) (2012)
• Type: Poster
• Poster code: PAA-P-05
• By: TODA, Takaki (Hokkaido Pharmaceutical University School of Pharmacy, Clinical Pharmacology, Otaru, Japan)
• Co-author(s): Senda, A. (Hokkaido Pharmaceutical University School of Pharmacy, Otaru, Japan)
  Riu, Y. (Hokkaido Pharmaceutical University School of Pharmacy, Otaru, Japan)
  Fujioka, K. (Hokkaido Pharmaceutical University School of Pharmacy, Otaru, Japan)
  Hosokawa, A. (Hokkaido Pharmaceutical University School of Pharmacy, Otaru, Japan)
  Yoshimura, K. (Hokkaido Pharmaceutical University School of Pharmacy, Otaru, Japan)
  Hayakawa, T. (Hokkaido Pharmaceutical University School of Pharmacy, Otaru, Japan)
  Inotsume, N. (Hokkaido Pharmaceutical University School of Pharmacy, Otaru, Japan)
  Ask, B. (Karolinska Institutet, Stockholm, Sweden)
  Rane, A. (Karolinska Institutet, Stockholm, Sweden)
  Eliasson, E. (Karolinska Institutet, Stockholm, Sweden)
  
• Abstract:

  I. Background
  Arachidonic acid (AA) metabolites, in particular epoxyeicosatrienoic acids (EETs) have been implicated in the regulation of vascular tone. We have demonstrated previously that losartan, an angiotensin II receptor blocker (ARB), decreases the formation of EETs from AA in vitro , by inhibiting human cytochrome P4502C9 (CYP2C9).

  II. Aim
  Our

  ..

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