Effect of antioxidants on the stability of ONO-1301, a novel long-acting prostacyclin agonist, loaded in PLGA microspheres

• In: Posters
• At: Amsterdam (the Netherlands) (2012)
• Type: Poster
• Poster code: FDP-P-29
• By: UCHIDA, Takahiro (Mukogawa Womens University, Faculty of Pharmaceutical Sciences, Nishinomiya city, Japan)
• Co-author(s): Hazekawa, M. (Mukogawa Womens University, Nishinomiya city, Japan)
  Yoshida, M. (Mukogawa Womens University, Nishinomiya city, Japan)
  
• Abstract:

  The purpose of this study was to evaluate the effect of antioxidant on the stability of poly(lactide-co-glycolide) microspheres (PLGA MS) containing ONO-1301, a novel long-acting prostacyclin agonist.Firstly, the structural formula of the degradation product of ONO-1301 was determined using liquid chromatography–nuclear magnetic resonance/mass

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