Application of chemometrics, pls, to second-order derivative spectrophotometric determination of benzene as impurity in ethanol and isopropyl alcohol.

• In: SIG Quality of Pharmaceuticals - Poster Session
• At: Cairo (Egypt) (2005)
• Type: Poster
• Poster code: QP-P-008
• By: WAHBI, Abdelaziz (University of Alexandria, Pharm. Analytical Chemistry, Alexandria, Egypt)
• Co-author(s): Hassan (University of Alexandria, ALEXANDRIA, Egypt)
  Fahmy (University of Alexandria, ALEXANDRIA, Egypt)
  Hamdy (University of Alexandria, ALEXANDRIA, Egypt)
  
• Abstract:

  Benzene is assayed as an impurity in ethanol, I and isopropyl alcohol, II at a level of 2 ppm using GC methods (B.P. 2004) . The multivariate method of analysis (PLS) has been applied to develop a rapid, simple and direct spectrophotometric method for this purpose. Second-order derivative data has been recorded for I and II in 5 cm and 1 cm..

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