Formulation and biological evaluation of glimepiride - cyclodextrin - polymer systems

• In: SIG Bioavailability / Bioequivalence - Poster Session
• At: Cairo (Egypt) (2005)
• Type: Poster
• Poster code: BB-P-008
• By: MAHMOUD, Azza (Dokki, National Research Center, Cairo, Egypt)
• Co-author(s): Ammar (Department of Pharmaceutical Sciences, N, CAIRO, Egypt)
  Salama (Department of Pharmaceutical Sciences, N, CAIRO, Egypt)
  Ghorab (Faculty of Pharmacy, Cairo University, CAIRO, Egypt)
  Mahmoud (Department of Pharmaceutical Sciences, N, CAIRO, Egypt)
  
• Abstract:

  Glimepiride is one of the third generation sulfonylureas used for treatment of type 2 diabetes. Poor aqueous solubility and slow dissolution rate of the drug lead to irreproducible clinical response or therapeutic failure in some cases due to subtherapeutic plasma drug levels. Consequently, the rationale of this study was to improve the biological ..

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