Lps-induced inflammation alters the disposition of fexofenadine in the isolated perfused rat liver.

• In: SIG Bioavailability / Bioequivalence - Poster Session
• At: Cairo (Egypt) (2005)
• Type: Poster
• Poster code: BB-P-005
• By: DAVEY, Andrew (University of South Australia, Centre for Pharmaceutical Research, Adelaide, Australia)
• Co-author(s): Tong (University of South Australia, ADELAIDE, Australia)
  Zhang (University of South Australia, ADELAIDE, Australia)
  Ngo (University of South Australia, ADELAIDE, Australia)
  
• Abstract:

  AIM: To examine the effect of bacterial lipopolysaccharide (LPS) on the pharmacokinetics of fexofenadine (an OATP and P-gp substrate) in the isolated perfused liver. METHODS: Male SD rats were divided into 4 groups (n=4): 1 control group and 3 treatment groups. Inflammation was induced in the 3 treatment groups by either 5, 2.5 or 1mg/kg i.p. of..

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