Synthesis and pharmacological evaluation of alkylene-linked bis-pyridinium monooximes as possible antidotes in organophosphate pesticide poisoning.

• In: Military and Emergency Pharmacy Section Posters
• At: New Orleans (USA) (2004)
• Type: Poster
• Poster code: MEPS-P006
• By: CHENNAMANENI, Chennamaneni Sriniv (University College of Pharm.Sciences, NDDS Laboratory, Andhra Pradesh, India)
• Co-author(s): Vobalaboina, Venkateswarlu (Kakatiya University, India)
  Garlapati, Achaiah (University College of Pharm.Sciences, India)
  
• Abstract:

  Introduction: Organohposphorous compounds have been used as chemical weapons and as pesticides. The mechanism of organophosphate poisoning involves phosphorylation of a serine hydroxyl group in the active site of acetylcholinesterase (AchE), leading to inactivation of this essential enzyme. The therapeutic approach to organophosphate poisoning is..

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