Investigation of stability and pharmacokinetics of a interleukin-2 liposome formulation for pulmonary administration

• In: SIG: Pharmaceutical Biotechnology - Posters
• At: Basel (Switzerland) (2008)
• Type: Poster
• Poster code: PB-P-007
• By: ÇELEBI, Nevin (Gazi University Faculty of Pharmacy Department of Pharmaceutical Technology, Ankara, Turkey)
• Co-author(s): Çilek, Ayse (Gazi University Faculty of Pharmacy Department of Pharmaceutical Technology, ANKARA, Turkey)
  Yücel, Aysegül (Gazi University School of Medicine Department of Immunology, Ankara, Turkey)
  Akbulut, Gonca (Gazi University School of Medicine Department of Physiology, Ankara, Turkey)
  
• Abstract:

  The objective of this study was to prepare a stable liposome formulation of interleukin-2 (IL-2). Another objective is to examine the effects of pulmonary administration of IL-2 liposome and solution dosage form on plasma IL-2 levels in rats. The pharmacokinetics and bioavailability parameters were also calculated. The stability of the liposome ..

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