Novel itraconazole-loaded solid dispersion with surface-attached method using poloxamer and polyvinylpyrrolidone

• In: Industrial Pharmacy - Posters
• At: Basel (Switzerland) (2008)
• Type: Poster
• Poster code: IPS-P-031
• By: YONG, Chul Soon (College of Pharmacy, Yeungnam University, Gyeongsan-si, Gyeongsangbuk-do, South-Korea)
• Co-author(s): Xuan, Jing Ji (College of Pharmacy, Yeungnam University, GYEONGSAN-SI, GYEONGSANGBUK-DO, South-Korea)
  Li, Dong Xun (College of Pharmacy, Yeungnam University, GYEONGSAN-SI, GYEONGSANGBUK-DO, South-Korea)
  Kim, Jung-Ae (College of Pharmacy, Yeungnam University, GYEONGSAN-SI, GYEONGSANGBUK-DO, South-Korea)
  Woo, Jong Soo (College of Pharmacy, Yeungnam University, GYEONGSAN-SI, GYEONGSANGBUK-DO, South-Korea)
  Yoo, Bong Kyu (College of Pharmacy, Yeungnam University, GYEONGSAN-SI, GYEONGSANGBUK-DO, South-Korea)
  Kim, Young Ran (College of Pharmacy, Yeungnam University, GYEONGSAN-SI, GYEONGSANGBUK-DO, South-Korea)
  Choi, Han-Gon (College of Pharmacy, Yeungnam University, GYEONGSAN-SI, GYEONGSANGBUK-DO, South-Korea)
  
• Abstract:

  Purpose. To develop novel itraconazole (ITR)-loaded surface attached solid dispersion using poloxamer and polyvinylpyrrolidone (PVP.)
  
  Methods. The effect of poloxamer, PVP and citric acid on the aqueous solubility of ITR was investigated. The solid dispersion was characterized by differential scanning calorimetry (DSC), X-ray diffraction (XRD),..

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