Conformational studies of [3.3.1]azabicycles, synthetic analogues of norditerpenoid alkaloids

• At: Glasgow (Scotland) (2018)
• Type: Poster
• Poster code: POS-NPR-024
• By: ZENG, Ziyu (University of Bath, Pharmacy and Pharmacology)
• Co-author(s): Ziyu Zeng: Pharmacy and Pharmacology, University of Bath, Bath, United Kingdom
  Michael Rowan: Pharmacy and Pharmacology, University of Bath, Bath, United Kingdom
  Ian Blagbrough: Pharmacy and Pharmacology, University of Bath, Bath, United Kingdom
  
• Abstract:

  Background

  Functional group substituents on cyclohexane (A) and piperidine (E) rings in the hexacyclic norditerpenoids isolated from Aconitum and Delphinium are key to the biological activities of these alkaloids.

  Methods

  Double Mannich reactions were used to synthesize the [3.3.1]azabicycles and then derivatives, e.g. 2,4-DNP, were prepared. The
  ..

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