Roles of cyp enzymes on formation of fluvastatin metabolites by human liver microsomes

• In: Posters - miscellaneous
• At: Basel (Switzerland) (2008)
• Type: Poster
• Poster code: M-P-003
• By: TODA, Takaki (Hokkaido Pharmaceutical University School of Pharmacy, Otaru, Japan)
• Co-author(s): Eliasson, Erik (Karolinska Institutet, Huddinge, Stockholm, Sweden)
  Ask, Birgitta (Karolinska Institutet, Huddinge, Stockholm, Sweden)
  Inotsume, Nobuo (Hokkaido Pharmaceutical University School of Pharmacy, OTARU, Japan)
  Rane, Anders (Karolinska Institutet, Huddinge, Stockholm, Sweden)
  
• Abstract:

  Fluvastatin is a HMG-CoA reductase inhibitor and is metabolized to 5-hydroxy fluvastatin (M-2), 6-hydroxy fluvastatin (M-3) and N-desisopropyl fluvastasin (M-5) in human liver microsomes by CYP enzymes. These metabolites have been considered to be primarily generated by CYP2C9. To elucidate the contribution of CYP enzymes on fluvastatin..

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