Comprehensive docking and refinement of human glutaminyl cyclase inhibitors for the drug discovery of alzheimer’s disease

• In: Poster presentation
• At: Seoul (South Korea) (2017)
• Type: Poster
• Poster code: POS-DDD-004
• By: CHOI, Sun (Ewha Womans University, Korea, Republic Of)
• Co-author(s): Sun Choi:
  Minghua Cui: College of Pharmacy and Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul, Korea, Republic Of
  Jongmi Park: College of Pharmacy and Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul, Korea, Republic Of
  Jeewoo Lee: College of Pharmacy, Seoul National University, Seoul, Korea, Republic Of
  
• Abstract:

  Background

  Glutaminyl cyclase (QC) is an enzyme catalyzing the N-terminal modification of glutamyl or glutaminyl precursors into pyroglutamate. The formation of pyroglutamate-modified Aβ peptide triggers the accumulation of Aβ oligomer and proto-fibrils causing neurotoxicity like brain cell death.

  Purpose

  Since these toxic materials aggravate..

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