Quantitative evaluation of absorption and metabolism of p-aminobenzoic acid in rat intestine

• In: Poster Presentation
• At: Stockholm (Sweden) (2017)
• Type: Poster
• Poster code: P-B-103-Tuesday
• By: OHURA, Kayoko (Kumamoto University, Priority Organization for Innovation and Excellence, Kumamoto, Japan)
• Co-author(s): Kayoko Ohura: Priority Organization for Innovation and Excellence, Kumamoto University, Kumamoto, Japan
  Keiichiro Tanaka: Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
  Takahiro Yonemitsu: Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
  Teruko Imai: Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
  
• Abstract:

  Backgrounds

  p-Aminobenzoic acid (PABA) has been long used as an indicator to assess the completeness of 24 hour urine collections. The urinary recovery of PABA is above 85% after orally dosing. However, PABA is a substrate of arylamine N-acetyltransferase expressed in both human and rat intestine. The intestinal metabolism of PABA to N-acetyl-PABA..

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