Novel potent antimitotic heterocyclic ketones: synthesis, antiproliferative activity and structure-activity relationships

• In: G37 - Manufacturing and good manufacturing practice IPS (part 1) on Wednesday, 5 September 2007, 9:00-11:45
• At: Beijing (China) (2007)
• Type: Presentations + Posters
• By: HU, Laixing (Institute of Medicinal Biotechnology, Beijing, China)
• Co-author(s): Li, Zhuo-rong (Institute of Medicinal Biotechnology, Beijing, China)
  Jin, Jie (Institute of Medicinal Biotechnology, Beijing, China)
  Jiang, Jian-dong (Institute of Medicinal Biotechnology, Beijing, China)
  Boykin, David (Georgia State University, Atlanta, United States of America)
  
• Abstract:

  We have described the synthesis, antiproliferative activity and SAR of novel heterocyclic ketones by replacing sulfonamide linkage with a carbonyl group in the lead compound 9-Ethyl -N-(3,4,5-trimethoxyphenyl)-carbazole-3-sulfonamide 1. Most of the heterocyclic ketones showed strong cytotoxicities under 1 uM against CEM leukemia cells. The most

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