Rho-kinase pathway contributes to cardiac remodeling in aldosterone/salt-induces hypertensive rats

• In: SIG Pharmaceutical Biotechnology - Posters
• At: Beijing (China) (2007)
• Type: Poster
• Poster code: PB-P-010
• By: GUO, Peng (Institute of Materia Medica, Beijing, China)
• Co-author(s): Wang, Xiao Liang (Institute of Materia Medica, BEIJING, China)
  Nishiyama, Akira (Kagawa University Medical School, KAGAWA, Japan)
  Kohno, Masakazu (Kagawa University Medical School, KAGAWA, Japan)
  
• Abstract:

  Recent studies indicate that Rho-kinase is involved in cardiovascular injury. We examined the effects a Rho-kinase inhibitor, fasudil, on the progression of cardiovascular injury in aldosterone/salt-treated uninephrectmized rats. Uninephrectmized rats were treated with 1% NaCl in drinking water (n=6), 1%NaCl + aldosterone (0.75 microg/H, s.c.,..

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