Polyethylenimine-based antisense oligodeoxynucleotides of il-4 suppress the production of il-4 in a murine model of airway inflammation

• In: SIG Pharmaceutical Biotechnology - Poster Session
• At: Salvadore (Brazil) (2006)
• Type: Poster
• Poster code: PB-P-005
• By: KIM, Chong-Kook (Seoul National University, Seoul, South-Korea)
• Abstract:

  Purpose. Interleukin-4 (IL-4) plays a crucial role as an inflammatory mediator in allergic asthma via inducing Th2 inflammation, IgE synthesis, and eotaxin. To develop an effective therapeutic agent which specifically inhibits production of IL-4, antisense-oligodeoxynucleotides (AS-ODNs) against murine IL-4 mRNA were generated and complexed with..

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