The association between ugt1a1*28 and survival after irinotecan chemotherapy: a collaborative systematic review and meta-analysis

• In: Posters J - Translational Research and Individualized Medicines
• At: PSWC, Melbourne (Australia) (2014)
• Type: Poster
• Poster code: PJ-008
• By: DIAS, Mafalda M. (University of South Australia, School of Pharmacy and Medical Sciences, Adelaide, Australia)
• Co-author(s): Mckinnon, Ross A. (Flinders University, Adelaide, Australia)
  Sorich, Michael J. (Flinders University, Adelaide, Australia)
  
• Abstract:

  Background: Individuals possessing uridine diphosphate-glucuronosyltransferase (UGT) 1A1*28 alleles have a greater risk of developing irinotecan-related toxicity (neutropenia and diarrhoea), compared with patients without these alleles. It has been proposed that UGT1A1*28 genotyping may be used to pre-emptively dose reduce irinotecan for UGT1A1*28 ..

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