Receptors and applications in biology and personalized medicine: CCR5/CXCR4receptors and fusion inhibitors in HIV-1 disease

• In: F5 - Pharmacogenomics - fundamental basis and use in therapeutics on Monday, 7 September 2009, 14:00-17:00
• At: Istanbul (Turkey) (2009)
• Type: Presentation
• By: GOFF, Stephen P. (Columbia University, Columbia, United States of America)
• Abstract:

  The HIV-1 envelope protein mediates entry of the virus into the cell through a specific receptor (CD4) and various coreceptors on the cell surface. Virus isolates typically exhibit a selectivity for utilization of either CCR5 (R5 virus), CXCR4 (X4 virus), or both (dual tropic virus). While the initially transmitted isolates are almost always R5

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