Enhanced oral bioavailability of flurbiprofen by the combined use of polysorbate 80 and ?-cyclodextrin

• In: Industrial Pharmacy- Posters
• At: Istanbul (Turkey) (2009)
• Type: Poster
• Poster code: IPS-P-020
• By: YONG, Chul Soon (College of Pharmacy, Yeungnam University, Gyeongsangbuk-do, South-Korea)
• Co-author(s): Lee, Won Seok (College of Pharmacy, Yeungnam University, GYEONGSANGBUK-DO, South-Korea)
  Han, Myo Jeong (College of Pharmacy, Yeungnam University, GYEONGSANGBUK-DO, South-Korea)
  Yoo, Bong Kyu (College of Pharmacy, Yeungnam University, GYEONGSANGBUK-DO, South-Korea)
  Woo, Jong Soo (College of Pharmacy, Yeungnam University, GYEONGSANGBUK-DO, South-Korea)
  Lee, Young-Im (College of Pharmacy, Yeungnam University, GYEONGSANGBUK-DO, South-Korea)
  Choi, Han-Gon (College of Pharmacy, Yeungnam University, GYEONGSANGBUK-DO, South-Korea)
  
• Abstract:

  The main objective of this study was to study the effect of the mixed system containing surfactant micelle and -cyclodextrin on the solubility of poorly water-soluble drug flurbiprofen, and evaluate its in vitro and in vivo performance. The mixed system was characterized by solubility study and phase solubility study in -cyclodextrin,..

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