Improved solubility, dissolution and bioavailability of sibutramine free base via solid dispersions prepared with hpmc2910, poloxamer407 and citric acid

• In: Industrial Pharmacy - Posters
• At: Basel (Switzerland) (2008)
• Type: Poster
• Poster code: IPS-P-026
• By: YONG, Chul Soon (College of Pharmacy, Yeungnam University, Gyeongsan-si, Gyeongsangbuk-do, South-Korea)
• Co-author(s): Jang, Ki Young (College of Pharmacy, Yeungnam University, GYEONGSAN-SI, GYEONGSANGBUK-DO, South-Korea)
  Lee, Won Mo (College of Pharmacy, Yeungnam University, GYEONGSAN-SI, GYEONGSANGBUK-DO, South-Korea)
  Lee, Jong Suk (College of Pharmacy, Yeungnam University, GYEONGSAN-SI, GYEONGSANGBUK-DO, South-Korea)
  Li, Dong Xun (College of Pharmacy, Yeungnam University, GYEONGSAN-SI, GYEONGSANGBUK-DO, South-Korea)
  Woo, Jong Soo (College of Pharmacy, Yeungnam University, GYEONGSAN-SI, GYEONGSANGBUK-DO, South-Korea)
  Rhee, Jong-Dal (College of Pharmacy, Yeungnam University, GYEONGSAN-SI, GYEONGSANGBUK-DO, South-Korea)
  Hong, Myung-Ja (College of Pharmacy, Yeungnam University, GYEONGSAN-SI, GYEONGSANGBUK-DO, South-Korea)
  Lee, Young-Im (College of Pharmacy, Yeungnam University, GYEONGSAN-SI, GYEONGSANGBUK-DO, South-Korea)
  Choi, Han-Gon (College of Pharmacy, Yeungnam University, GYEONGSAN-SI, GYEONGSANGBUK-DO, South-Korea)
  
• Abstract:

  Solid dispersions prepared with various ratios of poloxamer407, citric acid and HPMC2910 were prepared by surface-attached method and evaluated for improvement of solubility, dissolution and bioavailability of sibutramine free base. The inlet and outlet temperature of spray drying were 110? and 65?, respectively with 5% pump rate and 90 %..

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