A quality-by-design approach for highly systematic optimization of lipid-polymer hybrid nanoparticles toward efficient and safe intracellular delivery of siRNA cargo

• In: Short Communications C2 on Tuesday, 23 May 2017, 11:15-12:30
• At: Stockholm (Sweden) (2017)
• Type: Presentation
• By: THANKI, Kaushik (University of Copenhagen, Department of Pharmacy, Copenhagen, Denmark)
• Co-author(s): Kaushik Thanki: Department of Pharmacy, University of Copenhagen, Copenhagen, Denmark
  Xianghui Zeng: Department of Pharmacy, University of Copenhagen, Copenhagen, Denmark
  Sarah Justesen: Department of Pharmacy, University of Copenhagen, Copenhagen, Denmark;Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark
  Sarah Tejlmann: Department of Pharmacy, University of Copenhagen, Copenhagen, Denmark
  Emily Falkenberg: Department of Pharmacy, University of Copenhagen, Copenhagen, Denmark
  Hanne Mørck Nielsen: Department of Pharmacy, University of Copenhagen, Copenhagen, Denmark
  Henrik Franzyk: Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark
  Camilla Foged: Department of Pharmacy, University of Copenhagen, Copenhagen, Denmark
  
• Abstract:

  Backgrounds

  RNA interference therapy is highly target-specific and is mediated by small interfering RNA (siRNA).

  Aims

  The aim of the study was to apply a quality-by-design approach for the systematic optimization of siRNA-loaded lipid-polymer hybrid nanoparticles (LPNs) composed of lipid-like materials (lipidoids) and poly(DL-lactide-co-glycolide
  ..

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