Induction of UDP-glucuronosyltransferase 1A1 during the perinatal period can reduce blood thyroxine levels, causing neurodevelopmental toxicity

• In: Short oral presentations, Part 1 (Industry & Science) on Monday, 29 August 2016, 15:00-15:15
• At: Buenos Aires (Argentina) (2016)
• Type: Presentation
• By: FUJIWARA, Ryoichi (Kitasato University, School of Pharmacy, Tokyo, Japan)
• Co-author(s): Ryoichi Fujiwara:School of Pharmacy,Kitasato University,Tokyo,Japan|Yuki Kutsuno:School of Pharmacy,Kitasato University,Tokyo,Japan|Tomoo Itoh:School of Pharmacy,Kitasato University,Tokyo,Japan
  
• Abstract:

  Clinical data indicate that anticonvulsants such as phenytoin increase a risk of developing neurodevelopmental disorders; however, the underlying mechanism has not been elucidated. Thyroxine (T4) plays crucial roles in the development of the central nervous system. It has been reported that phenytoin can induce UDP-glucuronosyltransferase (UGT)

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