Ubiquitin-proteasome system as a cellular defense mechanism against methylmercury-induced cytotoxicity

• In: SIG Pharmaceutical Biotechnology Posters
• At: New Orleans (USA) (2004)
• Type: Poster
• Poster code: PB-P002
• By: HWANG, Gi-Wook (Tohoku University, Graduate School of Pharm. Sci., Sendai, Japan)
• Co-author(s): Furuchi (Tohoku University, SENDAI, Japan)
  Naganuma (Tohoku University, SENDAI, Japan)
  
• Abstract:

  We have recently identified CDC34 (also referred to as UBC3) as a methylmercury resistance gene. CDC34 encodes one of the ubiquitin-conjugating enzymes that catalyze ubiquitin transfer onto substrate proteins, a important step for protein degradation via ubiquitin-proteasome pathway. To elucidate the mechanism how Cdc34 reduce the yeast..

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