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A Novel Drug Delivery System for Diltiazem Hydrochloride

  • At: 2013 FIP Congress in Dublin (Ireland)
  • Type: Poster
  • By: EL HOFFY, Nada (Future University in Egypt, Pharmaceutical Technology Department, Cairo, Egypt)
  • Co-author(s): Ammar, Hussein (Future University in Egypt, Cairo, Egypt)
    Ibrahim, Magdy (Cairo University, Cairo, Egypt)
    Haider, Mohamed (University of Sharjah, Sharjah, United Arab Emirates)
  • Abstract:


    Diltiazem hydrochloride (DLT)

    is a class III anti-anginal, and a class IV antiarrhythmic calcium channel blocker undergoing extensive first pass metabolism with an absolute bioavailability of 40%.

    Formulating
    DLT

    in the form of
    intranasal niosomal

    dosage form may offer an alternative to the oral route, since niosomes protect the hydrophilic drug


    ..

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Last update 4 October 2019

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