Pk/pd evaluation of protein binding of ceftriaxone and levofloxacin in seriously ill patients

• At: Glasgow (Scotland) (2018)
• Type: Poster
• Poster code: POS-PAA-012
• By: SCOULAR, Sarah (University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, Clinical Pharmacy)
• Co-author(s): Sarah Scoular: Clinical Pharmacy, University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, Aurora, United States
  Ashley Hall
  Sanjana Rao: University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, ;, University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, Aurora, United States
  Scott Mueller: Clinical Pharmacy, University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, Aurora, United States
  Ty Kiser: Clinical Pharmacy, University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, Aurora, United States
  Doug Fish: Clinical Pharmacy, University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, Aurora, United States
  
• Abstract:

  Background

  Protein deficiency in seriously ill patients may lead to increased unbound serum concentrations of highly protein bound antibiotics potentially leading to improved clinical outcomes.

  Methods

  Patients ≥18 years of age with creatinine clearance ≥50 ml/minute were prospectively enrolled into PK studies of ceftriaxone (CRO) and levofloxacin
  ..

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